2 型糖尿病和糖尿病前期：2000-2018 年中东和北非育龄期妇女患病率研究的系统评价和荟萃分析。
Type 2 diabetes and pre-diabetes mellitus: a systematic review and meta-analysis of prevalence studies in women of childbearing age in the Middle East and North Africa, 2000-2018.
机构信息
Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates.
Department of Biology, College of Sciences, United Arab Emirates University, P.O. Box 15551, Al Ain, United Arab Emirates.
出版信息
Syst Rev. 2019 Nov 8;8(1):268. doi: 10.1186/s13643-019-1187-1.
BACKGROUND
Investing in women's health is an inevitable investment in our future. We systematically reviewed the available evidence and summarized the weighted prevalence of type 2 diabetes (T2DM) and pre-diabetes mellitus (pre-DM) in women of childbearing age (15-49 years) in the Middle East and North African (MENA) region.
METHODS
We comprehensively searched six electronic databases to retrieve published literature and prevalence studies on T2DM and pre-DM in women of childbearing age in the MENA. Retrieved citations were screened and data were extracted by at least two independent reviewers. Weighted T2DM and pre-DM prevalence was estimated using the random-effects model.
RESULTS
Of the 10,010 screened citations, 48 research reports were eligible. Respectively, 46 and 24 research reports on T2DM and pre-DM prevalence estimates, from 14 and 10 countries, were included. Overall, the weighted T2DM and pre-DM prevalence in 14 and 10 MENA countries, respectively, were 7.5% (95% confidence interval [CI], 6.1-9.0) and 7.6% (95% CI, 5.2-10.4). In women sampled from general populations, T2DM prevalence ranged from 0.0 to 35.2% (pooled, 7.7%; 95% CI, 6.1-9.4%) and pre-DM prevalence ranged from 0.0 to 40.0% (pooled, 7.9%; 95% CI, 5.3-11.0%). T2DM was more common in the Fertile Crescent countries (10.7%, 95% CI, 5.2-17.7%), followed by the Arab Peninsula countries (7.6%, 95% CI, 5.9-9.5%) and North African countries and Iran (6.5%, 95% CI, 4.3-9.1%). Pre-DM prevalence was highest in the Fertile Crescent countries (22.7%, 95% CI, 14.2-32.4%), followed by the Arab Peninsula countries (8.6%, 95% CI, 5.5-12.1%) and North Africa and Iran (3.3%, 95% CI, 1.0-6.7%).
CONCLUSIONS
T2DM and pre-DM are common in women of childbearing age in MENA countries. The high DM burden in this vital population group could lead to adverse pregnancy outcomes and acceleration of the intergenerational risk of DM. Our review presented data and highlighted gaps in the evidence of the DM burden in women of childbearing age, to inform policy-makers and researchers.
SYSTEMATIC REVIEW REGISTRATION
PROSPERO CRD42017069231.
背景
投资女性健康是对我们未来的必然投资。我们系统地回顾了现有证据，并总结了中东北非（MENA）地区育龄妇女（15-49 岁）的 2 型糖尿病（T2DM）和糖尿病前期（pre-DM）的加权患病率。
方法
我们全面检索了六个电子数据库，以检索关于 MENA 地区育龄妇女 T2DM 和 pre-DM 的已发表文献和患病率研究。筛选检索到的引文，并由至少两名独立审查员提取数据。使用随机效应模型估计加权 T2DM 和 pre-DM 患病率。
结果
在筛选出的 10010 条引文中，有 48 篇研究报告符合入选标准。分别有 46 篇和 24 篇关于 T2DM 和 pre-DM 患病率估计的研究报告来自 14 个和 10 个国家，被纳入研究。总体而言，14 个和 10 个 MENA 国家的加权 T2DM 和 pre-DM 患病率分别为 7.5%（95%置信区间[CI]，6.1-9.0）和 7.6%（95%CI，5.2-10.4）。在来自普通人群的女性样本中，T2DM 患病率范围为 0.0-35.2%（汇总，7.7%；95%CI，6.1-9.4%），pre-DM 患病率范围为 0.0-40.0%（汇总，7.9%；95%CI，5.3-11.0%）。T2DM 在新月沃土国家（10.7%，95%CI，5.2-17.7%）更为常见，其次是阿拉伯半岛国家（7.6%，95%CI，5.9-9.5%）和北非国家和伊朗（6.5%，95%CI，4.3-9.1%）。在新月沃土国家，pre-DM 患病率最高（22.7%，95%CI，14.2-32.4%），其次是阿拉伯半岛国家（8.6%，95%CI，5.5-12.1%）和北非和伊朗（3.3%，95%CI，1.0-6.7%）。
结论
T2DM 和 pre-DM 在 MENA 国家的育龄妇女中很常见。在这个重要人群中，DM 负担高可能导致不良的妊娠结局，并加速 DM 在代际之间的风险。我们的综述提供了数据，并强调了育龄妇女 DM 负担证据中的差距，以为决策者和研究人员提供信息。
系统评价注册
PROSPERO CRD42017069231。
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