免疫抑制增加与卵巢癌腹水增加和预后不良有关。

Increased Immunosuppression Is Related to Increased Amounts of Ascites and Inferior Prognosis in Ovarian Cancer.

机构信息

Department of Gynecology and Obstetrics, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

Department of Oncology, Leuven Cancer Institute, Laboratory of Tumor Immunology and Immunotherapy, ImmunOvar Research Group, KU Leuven, Leuven, Belgium.

出版信息

Anticancer Res. 2019 Nov;39(11):5953-5962. doi: 10.21873/anticanres.13800.

DOI:10.21873/anticanres.13800

PMID:31704820

Abstract

BACKGROUND/AIM: The presence of ascites in ovarian cancer patients is considered a negative prognostic factor. The underlying mechanisms are not clearly understood.

MATERIALS AND METHODS

The amount of ascites was evaluated, preferably, using diffusion-weighted MRI at primary diagnosis in a retrospective cohort of 214 women with ovarian cancer, in an ordinal manner (amount of ascites: none, limited, moderate, abundant). In a prospective cohort comprising 45 women with ovarian cancer, IL-10 (interleukin), VEGF (vascular endothelial growth factor), TGF-β (transforming growth factor) and CCL-2 [chemokine (C-C) motif ligand 2] were measured at diagnosis (and at interval debulking, when available).

RESULTS

Gradually increasing amounts of ascites were correlated significantly, even after correction for FIGO stage, with reduced survival (p<0.0001) and stronger immunosuppression (IL10 and VEGF). Neoadjuvant chemotherapy reduced immunosuppression, which was observed as a reduction in CCL-2, IL-10 and VEGF.

CONCLUSION

The amount of ascites is an independent predictor of survival and correlates with increased immunosuppression.

摘要

背景/目的：卵巢癌患者出现腹水被认为是一个负面的预后因素。其潜在机制尚不清楚。

材料和方法

在一个包含 214 名卵巢癌患者的回顾性队列中，我们优选地在初次诊断时使用扩散加权 MRI 对腹水的量进行评估，采用序数方式（腹水的量：无、有限、中等、大量）。在一个包含 45 名卵巢癌患者的前瞻性队列中，我们在诊断时（以及在间隔减瘤术时，如果有的话）测量了白细胞介素 10（IL-10）、血管内皮生长因子（VEGF）、转化生长因子-β（TGF-β）和趋化因子（C-C）基序配体 2（CCL-2）。