中心母细胞-中心细胞性淋巴瘤的预后指标
Prognostic indicators in centroblastic-centrocytic lymphoma.
作者信息
Griffin N R, Howard M R, Quirke P, O'Brien C J, Child J A, Bird C C
机构信息
Department of Pathology, University of Leeds.
出版信息
J Clin Pathol. 1988 Aug;41(8):866-70. doi: 10.1136/jcp.41.8.866.
Abstract
The prognostic importance of ploidy and proliferative index (%S + G2) assessed by flow cytometry, mitotic and centroblast counts, and histological growth pattern were evaluated in biopsy specimens taken before treatment from 60 cases of centroblastic-centrocytic non-Hodgkin's lymphoma. Cases with a high proliferative index (greater than or equal to 18%) or DNA aneuploidy showed significantly poorer survival than those with a low proliferative index (less than 18%). A high mitotic count was also associated with a poor prognosis. On multiple regression analysis the flow cytometric assessments and mitotic counts were significant predictors of survival. Assessments of proliferative activity clearly have prognostic potential in centroblastic-centrocytic lymphoma and may permit more accurate characterisation of individual tumours.
摘要
通过流式细胞术评估的倍体和增殖指数（%S + G2）、有丝分裂计数和成中心细胞计数以及组织学生长模式的预后重要性，在60例中心母细胞-中心细胞型非霍奇金淋巴瘤治疗前获取的活检标本中进行了评估。增殖指数高（大于或等于18%）或DNA非整倍体的病例，其生存率明显低于增殖指数低（小于18%）的病例。高有丝分裂计数也与预后不良相关。在多元回归分析中，流式细胞术评估和有丝分裂计数是生存的重要预测指标。增殖活性评估在中心母细胞-中心细胞型淋巴瘤中显然具有预后潜力，并且可能允许对个体肿瘤进行更准确的特征描述。
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