Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences (Ceuta), University of Granada, 51001 Granada, Spain.
Instituto Investigación Biosanitaria, ibs.Granada, 18012 Granada, Spain.
Int J Mol Sci. 2020 Jul 21;21(14):5173. doi: 10.3390/ijms21145173.
Saliva is a highly versatile biological fluid that is easy to gather in a non-invasive manner-and the results of its analysis complement clinical and histopathological findings in the diagnosis of multiple diseases. The objective of this review was to offer an update on the contribution of salivary biomarkers to the diagnosis and prognosis of diseases of the oral cavity, including oral lichen planus, periodontitis, Sjögren's syndrome, oral leukoplakia, peri-implantitis, and medication-related osteonecrosis of the jaw. Salivary biomarkers such as interleukins, growth factors, enzymes, and other biomolecules have proven useful in the diagnosis and follow-up of these diseases, facilitating the early evaluation of malignization risk and the monitoring of disease progression and response to treatment. However, further studies are required to identify new biomarkers and verify their reported role in the diagnosis and/or prognosis of oral diseases.
唾液是一种用途广泛的生物流体，易于以非侵入性的方式采集，其分析结果可补充临床和组织病理学发现，有助于多种疾病的诊断。本综述旨在提供唾液生物标志物在口腔疾病（包括口腔扁平苔藓、牙周炎、干燥综合征、口腔白斑、种植体周围炎和药物相关性颌骨坏死）诊断和预后中的作用的最新信息。研究表明，白细胞介素、生长因子、酶和其他生物分子等唾液生物标志物可用于这些疾病的诊断和随访，有助于早期评估恶变风险以及监测疾病进展和治疗反应。然而，需要进一步研究以确定新的生物标志物，并验证其在口腔疾病诊断和/或预后中的报道作用。
