Hübner K F, Andrews G A, Buonocore E, Hayes R L, Washburn L C, Collmann I R, Gibbs W D
J Nucl Med. 1979 Jun;20(6):507-13.
Modification of the Bücherer-Strecker amino acid synthesis facilitated the production of DL-[11C]tryptophan and DL-[11C]valine for clinical trials in patients with proven or suspected pancreatic disease. Examples of rectilinear scans and tomographic images of the pancreas are presented in this initial paper. Positron computed tomography was done with the ORTEC ECAT system. Rapid localization of these C-11-labeled amino acids and fast clearance from the plasma permit almost immediate examination following i.v. injection. Illustrative images include the normal pancreas, pancreatitis, and pancreatic carcinoma. The use of positron tomobraphy with C-11-labeled DL-tryptophan and DL-valine appears to offer a new and promising diagnostic modality for the detection and study of pancreatic diseases.
对布赫勒-施特雷克尔氨基酸合成法的改进有助于生产DL-[11C]色氨酸和DL-[11C]缬氨酸，用于对已确诊或疑似胰腺疾病患者的临床试验。本文首次展示了胰腺的直线扫描和断层图像示例。使用ORTEC ECAT系统进行正电子计算机断层扫描。这些C-11标记的氨基酸能快速定位并从血浆中快速清除，静脉注射后几乎可立即进行检查。示例图像包括正常胰腺、胰腺炎和胰腺癌。使用C-11标记的DL-色氨酸和DL-缬氨酸进行正电子断层扫描似乎为胰腺疾病的检测和研究提供了一种新的、有前景的诊断方法。
