[New developments in topical pharmaceuticals].

Topical preparations are by far the most frequently used therapeutic or prophylactic pharmaceuticals by dermatologists. Although only a few new active ingredients in topical pharmaceuticals have reached the market in recent years, some innovative galenic concepts and strategies considering the intrinsic effect of topical preparations have been developed, and it is quite certain that we can count on more genuine innovations in the near future. In particular small molecules, but also biological drugs, can be expected to be delivered by topical preparations, especially for inflammatory diseases. Also, we await innovative strategies for the substitution or regulation of the physicochemical and microbiological barrier function of the skin, including completely new options relating to the application of ribonucleic acid derivatives or their inhibitors aiming at influencing gene expression. Overall, it can be stated that the potential of epicutaneous application will take shape in modern vehicle strategies and procedures that deploy the intrinsic effect of topical preparations and that progress in biotechnology and physical chemistry will become increasingly relevant in practice.