Wohlrab Johannes
Institut für angewandte Dermatopharmazie, Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland.
Hautarzt. 2019 Dec;70(12):953-959. doi: 10.1007/s00105-019-04505-1.
Topical preparations are by far the most frequently used therapeutic or prophylactic pharmaceuticals by dermatologists. Although only a few new active ingredients in topical pharmaceuticals have reached the market in recent years, some innovative galenic concepts and strategies considering the intrinsic effect of topical preparations have been developed, and it is quite certain that we can count on more genuine innovations in the near future. In particular small molecules, but also biological drugs, can be expected to be delivered by topical preparations, especially for inflammatory diseases. Also, we await innovative strategies for the substitution or regulation of the physicochemical and microbiological barrier function of the skin, including completely new options relating to the application of ribonucleic acid derivatives or their inhibitors aiming at influencing gene expression. Overall, it can be stated that the potential of epicutaneous application will take shape in modern vehicle strategies and procedures that deploy the intrinsic effect of topical preparations and that progress in biotechnology and physical chemistry will become increasingly relevant in practice.
局部用制剂是皮肤科医生目前最常使用的治疗或预防性药物。尽管近年来局部用药物中只有少数几种新的活性成分上市，但考虑到局部用制剂的内在作用，已经开发出了一些创新的药剂学概念和策略，而且可以肯定的是，在不久的将来我们有望看到更多真正的创新。特别是小分子药物，还有生物药物，有望通过局部用制剂给药，尤其是用于炎症性疾病。此外，我们期待有创新策略来替代或调节皮肤的物理化学和微生物屏障功能，包括与应用旨在影响基因表达的核糖核酸衍生物或其抑制剂相关的全新选择。总体而言，可以说经皮应用的潜力将体现在利用局部用制剂内在作用的现代载体策略和程序中，生物技术和物理化学的进展在实践中将变得越来越重要。
