Emergency Department, Daqing Longnan Hospital, Daqing, Heilongjiang, China.
Coronary Care Unit, Daqing Longnan Hospital, Daqing, Heilongjiang, China.
Clinics (Sao Paulo). 2019 Nov 7;74:e1237. doi: 10.6061/clinics/2019/e1237. eCollection 2019.
To explore the clinical significance and correlation of microRNA-21 (miR-21) and the neutrophil-lymphocyte ratio (NLR) in patients with acute myocardial infarction (AMI).
The observation group contained 184 patients, while the control group contained 150 patients. The expression of miR-21 in the serum of each group was detected by qRT-PCR.
A total of 184 patients and their family members were followed-up for 30 days, among which 35 patients died and 149 patients survived, resulting in a survival rate of 80.97%. According to univariate analysis, there were significant differences in age, cardiac troponin (cTn), heart rate, Killip grade, percutaneous coronary intervention (PCI) operation rate, miR-21 and NLR. In the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) values of miR-21 and NLR for the diagnosis of AMI were 0.909 and 0.868, respectively, and the area under the combined detection curve was 0.960. In the Kaplan-Meier survival analysis, the survival of patients with high miR-21 expression and NLR was significantly higher than that of patients with low miR-21 expression and NLR (p=0.027; p=0.001). The correlation showed that miR-21 expression in serum was positively correlated with the NLR in the observation group (r=0.528, p<0.05). cTn, heart rate, Killip classification, PCI operation rate, miR-21, NLR are independent risk factors for AMI.
miR-21 and NLR play a role in the diagnosis of AMI and can be used as predictors for the survival of AMI.
探讨微小 RNA-21（miR-21）和中性粒细胞与淋巴细胞比值（NLR）在急性心肌梗死（AMI）患者中的临床意义及相关性。
观察组包含 184 例患者，对照组包含 150 例患者。通过 qRT-PCR 检测各组血清中 miR-21 的表达情况。
对 184 例患者及其家属进行 30 天随访，其中死亡 35 例，存活 149 例，存活率为 80.97%。单因素分析显示，年龄、心肌肌钙蛋白（cTn）、心率、Killip 分级、经皮冠状动脉介入治疗（PCI）术率、miR-21 和 NLR 比较，差异有统计学意义。在受试者工作特征（ROC）分析中，miR-21 和 NLR 对 AMI 的诊断 AUC 值分别为 0.909 和 0.868，联合检测曲线的 AUC 值为 0.960。Kaplan-Meier 生存分析显示，高 miR-21 表达和 NLR 的患者的生存率明显高于低 miR-21 表达和 NLR 的患者（p=0.027;p=0.001）。相关性分析显示，观察组血清 miR-21 表达与 NLR 呈正相关（r=0.528，p<0.05）。cTn、心率、Killip 分级、PCI 术率、miR-21、NLR 是 AMI 的独立危险因素。
miR-21 和 NLR 在 AMI 的诊断中起作用，可作为 AMI 患者生存的预测因子。
