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1
CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells .CRISPR-Cas9 诱导的 t(11;19)/MLL-ENL 易位导致人类造血祖细胞白血病的发生。
Haematologica. 2017 Sep;102(9):1558-1566. doi: 10.3324/haematol.2017.164046. Epub 2017 Jun 1.
2
Efficient Recreation of t(11;22) EWSR1-FLI1 in Human Stem Cells Using CRISPR/Cas9.利用 CRISPR/Cas9 在人干细胞中高效重建 t(11;22) EWSR1-FLI1。
Stem Cell Reports. 2017 May 9;8(5):1408-1420. doi: 10.1016/j.stemcr.2017.04.014.
3
Intrinsic gene changes determine the successful establishment of stable renal cancer cell lines from tumor tissue.
Int J Cancer. 2017 Jun 1;140(11):2526-2534. doi: 10.1002/ijc.30674. Epub 2017 Mar 16.
4
Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.利用CRISPR-Cas9基因组编辑和同源定向修复生成条件性致癌染色体易位
J Pathol. 2017 May;242(1):102-112. doi: 10.1002/path.4883. Epub 2017 Mar 30.
5
In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.利用 CRISPR/Cas9 系统在体工程致癌染色体重排。
Nature. 2014 Dec 18;516(7531):423-7. doi: 10.1038/nature13902. Epub 2014 Oct 22.
6
Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.利用 RNA 引导的 CRISPR-Cas9 系统工程化人类肿瘤相关染色体易位。
Nat Commun. 2014 Jun 3;5:3964. doi: 10.1038/ncomms4964.
7
Spatial dynamics of chromosome translocations in living cells.活细胞中染色体易位的空间动力学。
Science. 2013 Aug 9;341(6146):660-4. doi: 10.1126/science.1237150.
8
Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.FUS-CHOP融合蛋白在永生化/转化的人间充质干细胞中的表达驱动黏液样脂肪肉瘤的形成。
Stem Cells. 2013 Oct;31(10):2061-72. doi: 10.1002/stem.1472.
9
Animal models of leukemia: any closer to the real thing?白血病的动物模型:更接近真实情况了吗?
Cancer Metastasis Rev. 2013 Jun;32(1-2):63-76. doi: 10.1007/s10555-012-9405-5.
10
Safe harbours for the integration of new DNA in the human genome.人类基因组中新 DNA 整合的安全港。
Nat Rev Cancer. 2011 Dec 1;12(1):51-8. doi: 10.1038/nrc3179.

Modeling mixed-lineage-rearranged leukemia initiation in CD34 cells: a "CRISPR" solution.

作者信息

Torres-Ruiz Raúl, Rodriguez-Perales Sandra, Bueno Clara, Menendez Pablo

机构信息

Molecular Cytogenetics and Genome Editing Unit, Human Cancer Genetics Program, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain

Josep Carreras Leukemia Research Institute and Department of Biomedicine, School of Medicine, University of Barcelona, Barcelona, Spain.

出版信息

Haematologica. 2017 Sep;102(9):1467-1468. doi: 10.3324/haematol.2017.173740.

DOI:10.3324/haematol.2017.173740
PMID:28860233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5685229/
Abstract
摘要