中性粒细胞在免疫系统中的作用：概述。
The Role of Neutrophils in the Immune System: An Overview.
机构信息
Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.
出版信息
Methods Mol Biol. 2020;2087:3-10. doi: 10.1007/978-1-0716-0154-9_1.
Neutrophils, also known as polymorphonuclear neutrophils (PMNs), have long been considered as the short-lived, nonspecific white cells that form pus-and also happen to kill invading microbes. Indeed, neutrophils were often neglected (and largely not considered) as immune cells. This historic view of neutrophils has changed considerably over the past several decades, and we now know that in addition to playing the predominant role in the clearance of bacteria and fungi, they have a major role in shaping the host response to infection and immune system homeostasis. The change in our view of the role of neutrophils in the immune system has been due in large part to the study of these cells in vitro. Such work has been made possible by new and/or improved methods and approaches used to investigate neutrophils. These methods are the focus of this volume.
中性粒细胞，也被称为多形核白细胞（PMN），长期以来一直被认为是短暂的、非特异性的白细胞，形成脓液，并且碰巧杀死入侵的微生物。事实上，中性粒细胞经常被忽视（并且在很大程度上不被认为）作为免疫细胞。在过去的几十年里，我们对中性粒细胞的这种历史观点发生了很大的变化，我们现在知道，除了在清除细菌和真菌方面发挥主要作用外，它们在塑造宿主对感染的反应和免疫系统稳态方面也起着主要作用。我们对中性粒细胞在免疫系统中的作用的看法的改变在很大程度上是由于对这些细胞的体外研究。这些工作之所以成为可能，是因为使用了新的和/或改进的方法和方法来研究中性粒细胞。这些方法是本卷的重点。
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