帕金森病中的睡眠与昼夜节律障碍概述
Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease.
作者信息
Gros Priti, Videnovic Aleksandar
机构信息
Division of Neurology, University of Toronto, St. Michael's Hospital, 30 Bond Street, 3 Shuter, Office 3-040, Toronto, Ontario M5B 1W8, Canada.
Movement Disorders Unit, Division of Sleep Medicine, Massachusetts General Hospital, Harvard Medical School, Neurological Clinical Research Institute, 165 Cambridge Street, Suite 600, Boston, MA 02114, USA.
出版信息
Clin Geriatr Med. 2020 Feb;36(1):119-130. doi: 10.1016/j.cger.2019.09.005. Epub 2019 Sep 6.
Abstract
Sleep disorders are common among PD patients and affect quality of life. They are often under-recognized and under-treated. Mechanisms of sleep disorders in PD remain relatively poorly understood. Improved awareness of common sleep problems in PD. Tailored treatment and evidence for efficacy are lacking. The purpose of this review is to provide an overview and update on the most common sleep disorders in PD. We review specific features of the most common sleep disorders in PD, including insomnia, excessive daytime sleepiness, sleep-disordered breathing, restless legs syndrome, circadian rhythm disorders and REM sleep behavior disorders.
摘要
睡眠障碍在帕金森病患者中很常见，会影响生活质量。它们常常未得到充分认识和治疗。帕金森病睡眠障碍的机制仍相对了解不足。对帕金森病常见睡眠问题的认识有待提高。缺乏针对性的治疗方法和疗效证据。本综述的目的是概述和更新帕金森病最常见的睡眠障碍。我们回顾了帕金森病最常见睡眠障碍的具体特征，包括失眠、日间过度嗜睡、睡眠呼吸障碍、不宁腿综合征、昼夜节律障碍和快速眼动睡眠行为障碍。
相似文献
1
Overview of Sleep and Circadian Rhythm Disorders in Parkinson Disease.帕金森病中的睡眠与昼夜节律障碍概述
Clin Geriatr Med. 2020 Feb;36(1):119-130. doi: 10.1016/j.cger.2019.09.005. Epub 2019 Sep 6.
2
Sleep Issues in Parkinson's Disease and Their Management.帕金森病中的睡眠问题及其管理。
Neurotherapeutics. 2020 Oct;17(4):1480-1494. doi: 10.1007/s13311-020-00938-y. Epub 2020 Oct 7.
3
Disturbances of Sleep and Alertness in Parkinson's Disease.帕金森病的睡眠和警觉性障碍。
Curr Neurol Neurosci Rep. 2018 Apr 19;18(6):29. doi: 10.1007/s11910-018-0838-2.
4
A systematic review of the literature on disorders of sleep and wakefulness in Parkinson's disease from 2005 to 2015.2005 年至 2015 年帕金森病睡眠和觉醒障碍文献的系统回顾。
Sleep Med Rev. 2017 Oct;35:33-50. doi: 10.1016/j.smrv.2016.08.001. Epub 2016 Aug 31.
5
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease.帕金森病睡眠障碍的药物和非药物治疗。
Curr Neuropharmacol. 2021;19(12):2233-2249. doi: 10.2174/1570159X19666210517115706.
6
The Spectrum of Sleep Disorders in Parkinson Disease: A Review.帕金森病睡眠障碍的范围：综述。
Chest. 2021 Feb;159(2):818-827. doi: 10.1016/j.chest.2020.09.099. Epub 2020 Sep 19.
7
Sleep disturbances and excessive daytime sleepiness in Parkinson disease: an overview.帕金森病中的睡眠障碍与日间过度嗜睡：综述
J Neural Transm Suppl. 2006(70):349-55. doi: 10.1007/978-3-211-45295-0_53.
8
Current Update on Clinically Relevant Sleep Issues in Parkinson's Disease: A Narrative Review.目前帕金森病相关临床睡眠问题的最新研究进展：综述。
J Parkinsons Dis. 2021;11(3):971-992. doi: 10.3233/JPD-202425.
9
Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease.帕金森病的昼夜节律褪黑素节律与日间过度嗜睡。
JAMA Neurol. 2014 Apr;71(4):463-9. doi: 10.1001/jamaneurol.2013.6239.
10
Approaching disturbed sleep in late Parkinson's Disease: first step toward a proposal for a revised UPDRS.帕金森病晚期睡眠障碍的处理：迈向修订版统一帕金森病评定量表提案的第一步。
Parkinsonism Relat Disord. 2001 Oct;8(2):123-31. doi: 10.1016/s1353-8020(01)00026-8.
引用本文的文献
1
Animal Models for the Study of Neurological Diseases and Their Link to Sleep.用于研究神经疾病及其与睡眠关系的动物模型
Biomedicines. 2025 Aug 18;13(8):2005. doi: 10.3390/biomedicines13082005.
2
Sleep Characteristics in Individuals with Ehlers-Danlos Syndrome.埃勒斯-当洛综合征患者的睡眠特征
Med Sci (Basel). 2025 Jun 27;13(3):85. doi: 10.3390/medsci13030085.
3
Parkinson's Disease Sleep Scale-2: The Brazilian Version's Cross-Cultural Adaptation and Validation.帕金森病睡眠量表-2：巴西版本的跨文化适应与验证
Sleep Sci. 2025 Mar 11;18(2):e182-e189. doi: 10.1055/s-0044-1791977. eCollection 2025 Jun.
4
BSCL2 and CDK5 are two genes associated with circadian rhythm disturbance in Parkinson's disease.BSCL2和CDK5是与帕金森病昼夜节律紊乱相关的两个基因。
Sci Rep. 2025 Jul 1;15(1):22096. doi: 10.1038/s41598-025-05580-2.
5
Narrative Review on Common Traits of Parkinson's Disease and Epilepsy.帕金森病与癫痫共同特征的叙述性综述
J Clin Med. 2025 Apr 15;14(8):2716. doi: 10.3390/jcm14082716.
6
Intersection of Sleep Disorders and Parkinson Disease: Unveiling the Bidirectional Relationship.睡眠障碍与帕金森病的交集：揭示双向关系
Mov Disord Clin Pract. 2025 Jan;12(1):11-20. doi: 10.1002/mdc3.14254. Epub 2024 Nov 7.
7
Identification of key genes and diagnostic model associated with circadian rhythms and Parkinson's disease by bioinformatics analysis.通过生物信息学分析鉴定与昼夜节律和帕金森病相关的关键基因及诊断模型。
Front Aging Neurosci. 2024 Oct 16;16:1458476. doi: 10.3389/fnagi.2024.1458476. eCollection 2024.
8
Sleep-Related Disorders in Parkinson's Disease: Mechanisms, Diagnosis, and Therapeutic Approaches.帕金森病中的睡眠相关障碍：机制、诊断与治疗方法
CNS Neurol Disord Drug Targets. 2025;24(2):132-143. doi: 10.2174/0118715273314675240820191447.
9
A diagnostic model for Parkinson's disease based on circadian rhythm-related genes.基于昼夜节律相关基因的帕金森病诊断模型。
J Transl Med. 2024 Jul 8;22(1):635. doi: 10.1186/s12967-024-05424-z.
10
Olfactory Dysfunction and Long-Term Trajectories of Sleep Disorders among early Parkinson's Disease: Findings from a Longitudinal Cohort.早期帕金森病患者的嗅觉功能障碍与睡眠障碍的长期轨迹：一项纵向队列研究的结果
Neuroepidemiology. 2025;59(1):68-77. doi: 10.1159/000539330. Epub 2024 May 20.
本文引用的文献
1
Barriers to reporting non-motor symptoms to health-care providers in people with Parkinson's.帕金森病患者向医疗保健提供者报告非运动症状的障碍。
Parkinsonism Relat Disord. 2019 Jul;64:220-225. doi: 10.1016/j.parkreldis.2019.04.014. Epub 2019 Apr 20.
2
Association between restless legs syndrome and other movement disorders.不宁腿综合征与其他运动障碍的关联。
Neurology. 2019 May 14;92(20):948-964. doi: 10.1212/WNL.0000000000007500. Epub 2019 Apr 19.
3
Clinical Features and Correlates of Excessive Daytime Sleepiness in Parkinson's Disease.帕金森病日间过度嗜睡的临床特征及相关因素
Front Neurol. 2019 Feb 19;10:121. doi: 10.3389/fneur.2019.00121. eCollection 2019.
4
Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.特发性 REM 睡眠行为障碍患者发生痴呆和帕金森病的风险及预测因素：一项多中心研究。
Brain. 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030.
5
Enlightened PD: A novel treatment for Parkinson disease?开明的帕金森病治疗方案：帕金森病的一种新型治疗方法？
Neurology. 2019 Mar 12;92(11):499-500. doi: 10.1212/WNL.0000000000007078. Epub 2019 Feb 15.
6
Effect of Three Hypopnea Scoring Criteria on OSA Prevalence and Associated Comorbidities in the General Population.三种低通气评分标准对普通人群阻塞性睡眠呼吸暂停患病率及相关合并症的影响。
J Clin Sleep Med. 2019 Feb 15;15(2):183-194. doi: 10.5664/jcsm.7612.
7
Chronotherapies for Parkinson's disease.帕金森病的时间治疗学。
Prog Neurobiol. 2019 Mar;174:16-27. doi: 10.1016/j.pneurobio.2019.01.002. Epub 2019 Jan 15.
8
Update on treatments for nonmotor symptoms of Parkinson's disease-an evidence-based medicine review.帕金森病非运动症状治疗的研究进展——基于循证医学的评价
Mov Disord. 2019 Feb;34(2):180-198. doi: 10.1002/mds.27602. Epub 2019 Jan 17.
9
Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson's disease.白天嗜睡可能是帕金森病中一种与睡眠质量无关的独立症状。
J Neurol. 2019 Mar;266(3):636-641. doi: 10.1007/s00415-018-09179-8. Epub 2019 Jan 3.
10
Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson's Disease: A Pilot Study.帕金森病患者的睡眠质量与左旋多巴肠凝胶输注：一项初步研究。
Parkinsons Dis. 2018 Nov 1;2018:8691495. doi: 10.1155/2018/8691495. eCollection 2018.
Zotero 插件