Yoshimi N, Sugie S, Iwata H, Niwa K, Mori H, Hashida C, Shimizu H
Department of Pathology, Gifu University School of Medicine, Japan.
Mutat Res. 1988 Oct;206(2):183-91. doi: 10.1016/0165-1218(88)90159-0.
The genotoxicity of a variety of aniline derivatives was examined by a DNA repair test with rat hepatocytes. Out of 37 aniline derivatives, 6 chemicals, i.e., 2,4,6-trimethylaniline (mesidine), 2,4-xylidine, 3,5-diaminobenzoic acid, 3,4-diaminochlorobenzene, 2-chloro-4-methylaniline and 4-chloro-N-methylaniline, elicited positive DNA repair responses. The results are in agreement with the bacterial mutagenicities with or without norharman of these compounds. Positive compounds of unknown carcinogenicity in the present assay, i.e., 3,5-diaminobenzoic acid, 2-chloro-4-methylaniline and 4-chloro-N-methylaniline are suspected of being potentially carcinogenic.
采用大鼠肝细胞DNA修复试验检测了多种苯胺衍生物的遗传毒性。在37种苯胺衍生物中，6种化学物质，即2,4,6-三甲基苯胺（联甲苯胺）、2,4-二甲基苯胺、3,5-二氨基苯甲酸、3,4-二氨基氯苯、2-氯-4-甲基苯胺和4-氯-N-甲基苯胺，引发了阳性DNA修复反应。这些结果与这些化合物在有或无去甲哈尔满情况下的细菌诱变性一致。在本试验中具有未知致癌性的阳性化合物，即3,5-二氨基苯甲酸、2-氯-4-甲基苯胺和4-氯-N-甲基苯胺，被怀疑具有潜在致癌性。
