Barkley Dalia, Yanai Itai
Institute for Computational Medicine, New York University School of Medicine, NY, USA.
Institute for Computational Medicine, New York University School of Medicine, NY, USA.
Trends Cancer. 2019 Nov;5(11):655-656. doi: 10.1016/j.trecan.2019.09.002. Epub 2019 Oct 14.
While intratumoral heterogeneity has been extensively studied in terms of genetic alterations and phenotypic properties such as drug resistance, only recently has single-cell RNA-seq begun to expose the remarkable transcriptional diversity within tumors. A recent study of glioblastoma by Neftel et al. supports the emerging notion of cancer cell states and demonstrates their plasticity.
虽然肿瘤内异质性已在基因改变和诸如耐药性等表型特性方面得到广泛研究，但直到最近单细胞RNA测序才开始揭示肿瘤内显著的转录多样性。Neftel等人最近对胶质母细胞瘤的一项研究支持了癌细胞状态这一新兴概念，并证明了它们的可塑性。
