Riahi-Zanjani Bamdad, Heidarzadegan Mostafa, Badibostan Hasan, Karimi Gholamreza
1Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
J Food Sci Technol. 2019 Nov;56(11):4795-4798. doi: 10.1007/s13197-019-03927-y. Epub 2019 Aug 2.
Due to nutritional facts of milk in human life, the quality assessment of dairy products is of the utmost importance. The aim of the current study was to determine the 17β-estradiol level in commercial pasteurized and sterilized milk brands in Mashhad, Iran. In this regard, 160 samples including 80 pasteurized (40 high-fat and 40 low-fat) and 80 sterilized milk (40 high-fat and 40 low-fat) of widely used brands from different supermarkets were collected. The mean level of 17β-estradiol was 8.2 ± 0.59 pg/ml. The mean amount of estradiol was found to be 7.6 ± 0.47, 7.9 ± 0.45, 8.6 ± 0.63, and 8.9 ± 0.54 pg/ml for the low-fat pasteurized, low-fat sterilized, high-fat pasteurized and high-fat sterilized milk, respectively. There was no significant difference between the amount of estradiol in pasteurized and sterilized milk. As expected, the level of estradiol was statistically higher in high fat milks than that of low-fat milks. Considering the levels of 17β-estradiol measured here and the maximum permissible daily level of external estradiol entered to body through edible products recommended by EU and CAC (3.5 µg), at least in the short term, there will be no remarkable impact on the endocrine system. However, judging the long-term effects of using these products is not easy and simple at all, as cancers develop during a long period of time and has a multifactorial etiology.
鉴于牛奶在人类生活中的营养事实，乳制品的质量评估至关重要。本研究的目的是测定伊朗马什哈德市市售巴氏杀菌奶和灭菌奶品牌中的17β-雌二醇水平。为此，从不同超市收集了160份样品，包括80份巴氏杀菌奶（40份高脂和40份低脂）和80份灭菌奶（40份高脂和40份低脂），这些都是广泛使用的品牌。17β-雌二醇的平均水平为8.2±0.59 pg/ml。低脂巴氏杀菌奶、低脂灭菌奶、高脂巴氏杀菌奶和高脂灭菌奶中雌二醇的平均含量分别为7.6±0.47、7.9±0.45、8.6±0.63和8.9±0.54 pg/ml。巴氏杀菌奶和灭菌奶中雌二醇的含量没有显著差异。正如预期的那样，高脂牛奶中雌二醇的水平在统计学上高于低脂牛奶。考虑到此处测得的17β-雌二醇水平以及欧盟和食品法典委员会推荐的通过食用产品进入人体的外部雌二醇的每日最大允许水平（3.5μg），至少在短期内，对内分泌系统不会有显著影响。然而，判断使用这些产品的长期影响绝非易事，因为癌症是在很长一段时间内发展的，并且具有多因素病因。
