Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.
Adv Exp Med Biol. 2022;1358:1-7. doi: 10.1007/978-3-030-89340-8_1.
Since the discovery by John MacLeod in 1943 that spermatozoa produce small amounts of hydrogen peroxide, a member of the so-called reactive oxygen species (ROS), the importance and functions of these highly reactive oxygen derivatives in physiology and pathology are a subject of numerous studies. It has been shown that they play essential roles, not only in causing oxidative stress if their concentration is excessively high, but also in triggering crucial cellular functions if their concentration is low. On the other hand, antioxidants counterbalance the action of ROS to maintain a fine balance between oxidation and reduction as an excessive amount of antioxidants leads to a condition called reductive stress and is as harmful as oxidative stress. This book "Oxidative Stress and Toxicity in Reproductive Biology and Medicine - A Comprehensive Update on Male Infertility" authoritatively summarizes the current knowledge of various causes of oxidative stress including various andrological conditions and environmental pollution as well as the physiological effects of ROS. Moreover, this book expands into the treatment of oxidative stress with antioxidants and phytomedicine, a rapidly developing area. As a first of its kind, this book also sheds light on the effects of the redox potential during the fertilization process and thus highlights the importance of the correct balance of oxidants and antioxidants, even in the culture medium in assisted reproduction. The editors have brought together an impressive group of renowned experts to share their knowledge on the topic of oxidative stress and its clinical management in andrology and assisted reproduction.
自 1943 年 John MacLeod 发现精子会产生少量过氧化氢以来，这种所谓的活性氧（ROS）的一种成员，这些高反应性氧衍生物在生理学和病理学中的重要性和功能一直是众多研究的主题。已经表明，它们不仅在浓度过高时会引起氧化应激，而且在浓度过低时也会触发关键的细胞功能。另一方面，抗氧化剂可以抵消 ROS 的作用，以在氧化和还原之间保持精细平衡，因为过多的抗氧化剂会导致一种称为还原性应激的情况，其危害与氧化应激一样大。这本名为《生殖生物学和医学中的氧化应激和毒性——男性不育症的综合更新》的书权威地总结了各种氧化应激原因的最新知识，包括各种男科疾病和环境污染，以及 ROS 的生理影响。此外，本书还扩展到了抗氧化剂和植物药治疗氧化应激的领域，这是一个快速发展的领域。作为同类书籍中的首例，本书还揭示了受精过程中氧化还原电势的影响，从而强调了在辅助生殖中，即使在培养基中，氧化剂和抗氧化剂的正确平衡也很重要。编辑们汇集了一群知名的专家，分享他们在男科和辅助生殖领域氧化应激及其临床管理方面的知识。
