Departments of Neurosurgery, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, 430-8558, Japan; Departments of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Departments of Neurosurgery, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, 430-8558, Japan; Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, 430-8558, Japan; Departments of Neurosurgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.
Neurosci Lett. 2020 Jan 18;716:134636. doi: 10.1016/j.neulet.2019.134636. Epub 2019 Nov 18.
AspireSR is a novel vagus nerve stimulation (VNS) device which detects ictal heart rate changes and automatically apply additional stimulus. We investigated the difference of the efficacy between AspireSR and preceding VNS models in patients with device replacement. We retrospectively reviewed the clinical data of 17 patients whose VNS devices were changed because of battery discharge. The rates of seizure reduction, the number of antiepileptic drugs (AEDs) used and device parameters between the two devices were evaluated. AspireSR improved significantly the rates of seizure reduction of the patients. Four patients out of 11 patients with low response to the preceding VNS models (no change or <50 % reduction) achieved>50 % seizure reduction. The AEDs used were not different in the observed periods. The device parameters were low setting in AspireSR compared to preceding VNS models. AspireSR decrease significantly seizure frequencies compared to the preceding VNS models. Change of the devices to AspireSR at the time of battery empty could be recommendable.
AspireSR 是一种新型的迷走神经刺激（VNS）设备，可检测到发作性心率变化并自动施加额外的刺激。我们研究了在设备更换的患者中，AspireSR 与之前的 VNS 模型的疗效差异。我们回顾性分析了 17 名因电池放电而更换 VNS 设备的患者的临床资料。评估了两种设备之间的癫痫发作减少率、抗癫痫药物（AED）的使用数量和设备参数。AspireSR 显著提高了患者的癫痫发作减少率。在之前对 VNS 模型反应不佳的 11 名患者中（无变化或<50%减少），有 4 名患者的癫痫发作减少率达到>50%。在观察期间使用的 AED 没有差异。与之前的 VNS 模型相比，AspireSR 的设备参数设置较低。与之前的 VNS 模型相比，AspireSR 显著降低了癫痫发作频率。在电池耗尽时将设备更换为 AspireSR 可能是值得推荐的。
