Department of Biomedical Sciences, Faculty of Medicine and Biomedical Sciences, MAHSA University, Jalan SP2, Bandar Saujana Putra, 42610 Jenjarom, Selangor, Malaysia.
Department of Biotechnology, School of Bio and Chemical Engineering, Sathyabama Institute of Science and Technology, Sholinganallur, Rajiv Gandhi Salai, Chennai, Tamil Nadu 600119, India.
Int J Biol Macromol. 2020 Jun 15;153:1024-1034. doi: 10.1016/j.ijbiomac.2019.10.232. Epub 2019 Nov 18.
Surface engineering of super paramagnetic iron oxide nanoparticles (SPIONs) favor the tagging of any molecule or compound onto it, encapsulating them with a biopolymer make them biocompatible and favor slow release of loaded molecules. Recovery of SPIONs is easier as they obey to external magnetic field. In this study, SPIONS were used for mosquito larvicidal activity after surface engineered with oleic acid to favor the tagging of Cyfluthrin (mosquito larvicidal agent), it was then encapsulated with gum polysaccharide derived from Azadirachta indica and Araucaria heterophylla. Every stage of coreshell formation was microscopically and spectroscopically characterized. The coreshell SPIONs produced using Azadirachta indica and Araucaria heterophylla gum derived polysaccharide encapsulation were found to be the size around 80 nm. Thus, prepared coreshell SPIONs was subjected for mosquito larvicidal activity against Culex sp. The coreshell SPIONs was efficiently killing the mosquito larva and its impact was studied by percentage mortality studies.
超顺磁性氧化铁纳米粒子（SPIONs）的表面工程有利于将任何分子或化合物标记在其上，用生物聚合物将其包裹使它们具有生物相容性，并有利于负载分子的缓慢释放。由于 SPIONs 遵循外部磁场，因此它们的回收更加容易。在这项研究中，SPIONs 经过油酸表面工程处理后，用于蚊虫幼虫的杀蚊活性，然后用从印楝和南洋杉中提取的多糖胶进行包裹。核心壳形成的每一个阶段都进行了显微镜和光谱学的特征描述。使用印楝和南洋杉胶衍生多糖进行包裹的核壳 SPIONs 的尺寸约为 80nm。因此，制备的核壳 SPIONs 被用于针对库蚊属的杀蚊活性。核壳 SPIONs 有效地杀死了蚊子幼虫，并通过死亡率研究来研究其影响。
