Cardiology, National Heart Centre Singapore, 5 Hospital Drive, Singapore, 169609, Singapore.
SingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.
BMC Cardiovasc Disord. 2019 Nov 21;19(1):259. doi: 10.1186/s12872-019-1248-3.
Cardiovascular disease (CVD) imposes much mortality and morbidity worldwide. The use of "deep learning", advancements in genomics, metabolomics, proteomics and devices like wearables have the potential to unearth new insights in the field of cardiology. Currently, in Asia, there are no studies that combine the use of conventional clinical information with these advanced technologies. We aim to harness these new technologies to understand the development of cardiovascular disease in Asia.
Singapore is a multi-ethnic country in Asia with well-represented diverse ethnicities including Chinese, Malays and Indians. The SingHEART study is the first technology driven multi-ethnic prospective population-based study of healthy Asians. Healthy male and female subjects aged 21-69 years old without any prior cardiovascular disease or diabetes mellitus will be recruited from the general population. All subjects are consented to undergo a detailed on-line questionnaire, basic blood investigations, resting and continuous electrocardiogram and blood pressure monitoring, activity and sleep tracking, calcium score, cardiac magnetic resonance imaging, whole genome sequencing and lipidomic analysis. Outcomes studied will include mortality and cause of mortality, myocardial infarction, stroke, malignancy, heart failure, and the development of co-morbidities.
An initial target of 2500 patients has been set. From October 2015 to May 2017, an initial 683 subjects have been recruited and have completed the initial work-up the SingHEART project is the first contemporary population-based study in Asia that will include whole genome sequencing and deep phenotyping: including advanced imaging and wearable data, to better understand the development of cardiovascular disease across different ethnic groups in Asia.
心血管疾病（CVD）在全球范围内导致了大量的死亡率和发病率。“深度学习”的应用、基因组学、代谢组学、蛋白质组学以及可穿戴设备等方面的进步，有可能在心脏病学领域发现新的见解。目前，亚洲还没有将常规临床信息与这些先进技术结合使用的研究。我们旨在利用这些新技术来了解亚洲心血管疾病的发展。
新加坡是亚洲的一个多民族国家，代表了包括华人、马来人和印度人在内的多样化民族。SingHEART 研究是亚洲首个采用先进技术的多民族前瞻性基于人群的健康亚洲人研究。年龄在 21-69 岁之间、无任何先前心血管疾病或糖尿病的健康男性和女性受试者将从普通人群中招募。所有受试者均同意接受详细的在线问卷调查、基本血液检查、静息和连续心电图及血压监测、活动和睡眠跟踪、钙评分、心脏磁共振成像、全基因组测序和脂质组学分析。研究的结果将包括死亡率和死因、心肌梗死、中风、恶性肿瘤、心力衰竭以及合并症的发展。
设定了 2500 例患者的初始目标。自 2015 年 10 月至 2017 年 5 月，已招募了最初的 683 名受试者，并完成了 SingHEART 项目的初始检查。该项目是亚洲首个当代基于人群的研究，将包括全基因组测序和深度表型分析：包括先进的成像和可穿戴设备数据，以更好地了解亚洲不同种族群体心血管疾病的发展情况。
