Birkeland S A, Kristoffersen K
Scand J Immunol. 1979;10(5):415-9. doi: 10.1111/j.1365-3083.1979.tb01370.x.
Immunological relationships in pregnancy were investigated in a longitudinal study of twenty-two pregnant women, whose blood samples were taken before pregnancy, during pregnancy, at delivery, and 3--5 months after delivery. Blood samples were also taken from the fathers and the infants, both at birth and after 3--5 months. All the samples were frozen by means of a cryobiological freezing system, and when a whole longtiudinal series had been collected, the material was thawed and tested in a single seance. T and B lymphocytes were studied with rosette tests (E and HEAC rosettes). T and B lymphocytes were found not to change during the course of pregnancy. It is thus concluded that the mother's tolerance of a fetus with a dissimilar tissue type is not exercised via changes in the total count of T and B lymphocytes, although there may well be changes in their subpopulations, with the hypothesis that T-suppressor function increases and B-lymphocyte function decreases.
在一项针对22名孕妇的纵向研究中，对妊娠期间的免疫关系进行了调查。在怀孕前、怀孕期间、分娩时以及分娩后3至5个月采集了她们的血样。还在婴儿出生时和出生后3至5个月采集了父亲和婴儿的血样。所有样本均通过低温生物学冷冻系统冷冻，当收集到完整的纵向系列样本后，将材料解冻并在一次检测中进行测试。通过玫瑰花结试验（E和HEAC玫瑰花结）研究T淋巴细胞和B淋巴细胞。研究发现，T淋巴细胞和B淋巴细胞在妊娠过程中没有变化。因此得出结论，母亲对具有不同组织类型胎儿的耐受性并非通过T淋巴细胞和B淋巴细胞总数的变化来实现，尽管其亚群可能存在变化，推测T抑制功能增强而B淋巴细胞功能减弱。
