Goebel C, Kock M, Merk H
COTY Wella Toxicology, Berliner Allee 65, 64295, Darmstadt, Deutschland.
Klinik für Dermatologie und Allergologie - Hautklinik, Universitätsklinikum Aachen, Aachen, Deutschland.
Hautarzt. 2019 Dec;70(12):948-952. doi: 10.1007/s00105-019-04510-4.
Resorcinol is a frequently used hair dye, whose quantitative risk assessment (QRA) for hair color products is presented in this review as an example to assess its skin sensitization risk after topical application. Its purpose is to determine the maximum concentration that can be used without expecting skin sensitization to occur. The focus is to prevent the de novo development of a contact allergy. Epidemiological data which are provided via dermatological surveillance, e.g., by the IVDK (Information Network of Departments of Dermatology) in Germany, are an important source of information that help to assess the quality and the effectivity of the QRA.
间苯二酚是一种常用的染发剂，本综述以染发剂为例介绍了其在染发产品中的定量风险评估（QRA），以评估其局部应用后的皮肤致敏风险。其目的是确定在不引发皮肤致敏的情况下可使用的最大浓度。重点在于预防新发接触性过敏。通过皮肤病学监测（例如德国皮肤病科信息网络IVDK提供的数据）获得的流行病学数据是有助于评估QRA质量和有效性的重要信息来源。
