Kleine Stephanie A, Gogal Robert M, George Clinton, Thaliath MaryAnn, Budsberg Steven C
Department of Small Animal Medicine and Surgery, University of Georgia, Athens, Georgia, United States.
Department of Veterinary Biosciences and Diagnostic Imaging, University of Georgia, Athens, Georgia, United States.
Vet Comp Orthop Traumatol. 2020 Mar;33(2):147-150. doi: 10.1055/s-0039-3399525. Epub 2019 Nov 22.
Chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) have been shown to cause monocyte and natural killer cell chemotaxis and polymorphonuclear cell chemotaxis, respectively. Additionally, MCP-1 signalling has been implicated in modulating pain. Elevated synovial fluid concentrations of MCP-1 and IL-8 have been demonstrated in humans with osteoarthritis, but currently there are no studies evaluating synovial MCP-1 or IL-8 concentrations in dogs. Additionally, there are no canine studies evaluating the correlation between these chemokines and caregiver perceived pain and mobility, as measured by the clinical metrology instrument, Liverpool Osteoarthritis in Dogs. This study documented elevated synovial fluid concentrations of IL-8 and MCP-1 in the stifle of dogs with secondary osteoarthritis compared with normal stifles. However, this study found no correlation between MCP-1 or IL-8 and Liverpool Osteoarthritis in Dogs or radiographic severity of osteoarthritis.
趋化因子，如单核细胞趋化蛋白-1（MCP-1）和白细胞介素-8（IL-8），已被证明分别可引起单核细胞和自然杀伤细胞趋化以及多形核细胞趋化。此外，MCP-1信号传导与疼痛调节有关。在患骨关节炎的人类中，已证实其滑液中MCP-1和IL-8浓度升高，但目前尚无评估犬类滑液中MCP-1或IL-8浓度的研究。此外，也没有犬类研究评估这些趋化因子与照护者所感知的疼痛及活动能力之间的相关性，后者通过临床计量仪器“犬类利物浦骨关节炎”进行测量。本研究记录了与正常 stifle 相比，继发性骨关节炎犬的 stifle 中滑液IL-8和MCP-1浓度升高。然而，本研究发现MCP-1或IL-8与“犬类利物浦骨关节炎”或骨关节炎的放射学严重程度之间无相关性。
