咪唑盐酸盐催化的迈克尔加成反应保护氨基并构建中环杂环。
Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles.
机构信息
Department of Medicinal Chemistry, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
出版信息
Molecules. 2019 Nov 20;24(23):4224. doi: 10.3390/molecules24234224.
Abstract
An effective approach for amino protection and construction of a seven-membered ring has been developed. The method uses imidazolium chloride to carry out the Michael addition reaction at low temperatures and perform amino deprotection or construction of a seven-membered ring at high temperatures.
摘要
已开发出一种有效的氨基酸保护和构建七元环的方法。该方法使用咪唑鎓氯化物在低温下进行迈克尔加成反应，并在高温下进行氨基脱保护或构建七元环。
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