普通菜豆蛋白水解物可调节脂代谢，防止致动脉粥样硬化饮食喂养的 BALB/c 小鼠发生内皮功能障碍。

Common bean protein hydrolysate modulates lipid metabolism and prevents endothelial dysfunction in BALB/c mice fed an atherogenic diet.

机构信息

Departamento de Nutrição e Saúde da Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, Campus Universitário, Viçosa, Minas Gerais, 36570-000, Brazil.

Departamento de Nutrição e Saúde da Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, Campus Universitário, Viçosa, Minas Gerais, 36570-000, Brazil; Faculdade Dinâmica do Vale do Piranga -FADIP, 205 G St, Paraiso, Ponte Nova, Minas Gerais, 35430-302, Brazil.

出版信息

Nutr Metab Cardiovasc Dis. 2020 Jan 3;30(1):141-150. doi: 10.1016/j.numecd.2019.07.020. Epub 2019 Jul 31.

DOI:10.1016/j.numecd.2019.07.020

PMID:31757569

Abstract

BACKGROUND AND AIMS

Common beans (Phaseolus vulgaris L.) protein hydrolysate is a source of bioactive peptides with known health benefits. The aim of this study was to evaluate the effect of common bean protein hydrolysate on lipid metabolism and endothelial function in male adult BALB/c mice fed an atherogenic diet for nine weeks.

METHODS AND RESULTS

Male adult mice were divided into three experimental groups (n = 12) and fed with normal control diet; atherogenic diet and atherogenic diet added with bean protein hydrolysate (700 mg/kg/day) for nine weeks. Food intake, weight gain, lipid profile, Atherogenic Index of Plasma, inflammation biomarkers and endothelial function were evaluated. APH group presented reduced feed intake, weight gain, lipid profile, tumor necrosis factor-α, angiotensin II (94% and 79%, respectively) and increased endothelial nitric oxide synthase (62%).

CONCLUSIONS

Protein hydrolysate showed hypocholesterolemic activity preventing inflammation and dysfunction of vascular endothelium, in addition to decreasing oxidative stress, indicating an adjuvant effect on reducing atherogenic risk.

摘要

背景与目的

普通豆（Phaseolus vulgaris L.）蛋白水解物是具有已知健康益处的生物活性肽的来源。本研究的目的是评估普通豆蛋白水解物对喂食致动脉粥样硬化饮食 9 周的雄性成年 BALB/c 小鼠脂质代谢和内皮功能的影响。

方法与结果

雄性成年小鼠分为三组（每组 12 只），分别喂食正常对照饮食、致动脉粥样硬化饮食和致动脉粥样硬化饮食添加豆蛋白水解物（700mg/kg/天）9 周。评估了食物摄入量、体重增加、血脂谱、血浆致动脉粥样硬化指数、炎症生物标志物和内皮功能。APH 组表现出降低的饲料摄入量、体重增加、血脂谱、肿瘤坏死因子-α、血管紧张素 II（分别降低 94%和 79%）和增加的内皮型一氧化氮合酶（62%）。