Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Respir Med. 2020 Jan;161:105821. doi: 10.1016/j.rmed.2019.105821. Epub 2019 Nov 19.
Cellular senescence has been linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF). CCN1 is a matricellular protein that has been shown to induce cellular senescence and contribute to lung fibrosis in pre-clinical models. In this report, we determined plasma CCN1 levels in patients with IPF and its potential role in clinical outcomes.
We evaluated 88 patients diagnosed with IPF at the University of Alabama at Birmingham. CCN1 levels were measured in plasma specimens by ELISA. The primary outcome measure was transplant-free survival (TFS) duration. High-CCN1 levels were associated with a lower transplant-free survival independent of %FVC and %DCO compared to patients with low plasma CCN1 (HR = 2.15; 95%CI 1.04-4.45, p = 0.04).
This study demonstrates that plasma levels of CCN1 may be predictive of survival in IPF. Given the plausible role of CCN1 in cellular senescence and pathobiology of IPF, the predictive value of CCN1 in disease progression among patients with IPF warrants further investigation.
细胞衰老与特发性肺纤维化（IPF）的发病机制有关。CCN1 是一种基质细胞蛋白，已被证明可诱导细胞衰老，并在临床前模型中导致肺纤维化。在本报告中，我们测定了 IPF 患者的血浆 CCN1 水平及其在临床结局中的潜在作用。
我们在阿拉巴马大学伯明翰分校评估了 88 例诊断为 IPF 的患者。通过 ELISA 法测定血浆标本中的 CCN1 水平。主要观察指标是无移植存活率（TFS）持续时间。与低血浆 CCN1 相比，高 CCN1 水平与较低的 TFS 独立于 %FVC 和 %DCO 相关（HR=2.15；95%CI 1.04-4.45，p=0.04）。
本研究表明，血浆 CCN1 水平可能可预测 IPF 的生存情况。鉴于 CCN1 在细胞衰老和 IPF 病理生物学中的潜在作用，CCN1 在 IPF 患者疾病进展中的预测价值值得进一步研究。
