Bahria University Medical and Dental College, Sailor's street DHA phase II, , Karachi, Pakistan.
Hamdard College of Medicine and Dentistry, Department of Orthodontics, Madinat al-Hikmah Hakim Mohammad Said Road, Karachi, Pakistan.
Int Orthod. 2020 Mar;18(1):10-21. doi: 10.1016/j.ortho.2019.10.002. Epub 2019 Nov 22.
The present study was aimed to assess the effectiveness of antimicrobial gels along with conventional tooth brushing to improve gingival health in patients undergoing fixed orthodontic treatment.
All randomized and non-randomized clinical trials done on human subjects were explored in major health science databases (PubMed, CINAHL Plus, EBSCO Dent & Oral Sciences and Cochrane). An additional manual search was done on Google Scholar and on www.clinicaltrials.gov to identify any grey literature and unpublished data. Date of publication was not restricted during the data search. The assessment of risk of bias was done using the Cochrane Collaboration's Risk of Bias assessment tool. The meta-analysis was done using Review Manager Version 5.3.5 to analyse probing depth to be in two and four-week follow-up. This systematic review is reported according to the PRISMA statement and registered at PROSPERO (CRD42018084530).
The electronic database search yielded 3733 records; hand search identified 14 articles meeting the selection criteria which were included in the qualitative data synthesis. Significant improvement in gingivitis has been reported using antioxidant-essential oil gel, cervitec gel (0.2% chlorhexidine), 2% chlorhexidine gel, amine fluoride gel, and 0.4% stannous fluoride gel with>98% availability of Sn ions. Three articles with probing depth as comparable parameter were used for quantitative analysis. At the two and four-week follow-up, overall insignificant differences were observed in the antimicrobial gel group compared to the control group with regard to probing depth.
The use of antioxidant-essential oil gel, amine fluoride gel, 0.4% stannous fluoride gel (98% availability of Sn) and 2% chlorhexidine gel resulted in significant improvement in gingivitis. However, probing depth in follow-up visits showed no significant difference between antimicrobial gel and control group.
本研究旨在评估抗菌凝胶联合常规刷牙对固定正畸治疗患者改善牙龈健康的效果。
在主要的健康科学数据库（PubMed、CINAHL Plus、EBSCO Dent & Oral Sciences 和 Cochrane）中搜索了所有针对人类受试者进行的随机和非随机临床试验。还在 Google Scholar 和 www.clinicaltrials.gov 上进行了额外的手动搜索，以确定任何灰色文献和未发表的数据。在数据搜索期间没有限制出版日期。使用 Cochrane 协作风险偏倚评估工具评估风险偏倚。使用 Review Manager Version 5.3.5 进行荟萃分析，以分析在两周和四周随访时的探诊深度。本系统评价按照 PRISMA 声明进行报告，并在 PROSPERO（CRD42018084530）注册。
电子数据库搜索产生了 3733 条记录；手动搜索确定了 14 篇符合选择标准的文章，这些文章被纳入定性数据综合分析。使用抗氧化-精油凝胶、 Cervitec 凝胶（0.2%洗必泰）、2%洗必泰凝胶、胺氟凝胶和 0.4%纳米氟化亚锡凝胶，报道了牙龈炎显著改善，这些凝胶的 Sn 离子可用性>98%。有三篇文章使用探诊深度作为可比参数进行定量分析。在两周和四周随访时，抗菌凝胶组与对照组在探诊深度方面总体无显著差异。
使用抗氧化-精油凝胶、胺氟凝胶、0.4%纳米氟化亚锡凝胶（98%的 Sn 可用性）和 2%洗必泰凝胶可显著改善牙龈炎。然而，在随访期间，探诊深度在抗菌凝胶组和对照组之间没有显著差异。
