Suppr超能文献

聚类大小不同的整群随机试验中计数结局的样本量计算

Sample Size Calculation for Count Outcomes in Cluster Randomization Trials with Varying Cluster Sizes.

作者信息

Wang Jijia, Zhang Song, Ahn Chul

机构信息

Department of Statistical Science, Southern Methodist University, Dallas, TX.

Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, TX.

出版信息

Commun Stat Theory Methods. 2020;49(1):116-124. doi: 10.1080/03610926.2018.1532004. Epub 2018 Dec 21.

Abstract

In many cluster randomization studies, cluster sizes are not fixed and may be highly variable. For those studies, sample size estimation assuming a constant cluster size may lead to under-powered studies. Sample size formulas have been developed to incorporate the variability in cluster size for clinical trials with continuous and binary outcomes. Count outcomes frequently occur in cluster randomized studies. In this paper, we derive a closed-form sample size formula for count outcomes accounting for the variability in cluster size. We compare the performance of the proposed method with the average cluster size method through simulation. The simulation study shows that the proposed method has a better performance with empirical powers and type I errors closer to the nominal levels.

摘要

在许多整群随机试验中,群的大小并非固定不变,可能差异很大。对于这些试验,假设群大小恒定来估计样本量可能会导致效能不足的试验。已开发出样本量公式,以纳入具有连续和二元结局的临床试验中群大小的变异性。计数结局在整群随机试验中经常出现。在本文中,我们推导了一个考虑群大小变异性的计数结局的封闭式样本量公式。我们通过模拟比较了所提出方法与平均群大小法的性能。模拟研究表明,所提出的方法具有更好的性能,其经验效能和I型错误更接近名义水平。

相似文献

1
Sample Size Calculation for Count Outcomes in Cluster Randomization Trials with Varying Cluster Sizes.
Commun Stat Theory Methods. 2020;49(1):116-124. doi: 10.1080/03610926.2018.1532004. Epub 2018 Dec 21.
2
Effect of Imbalance and Intracluster Correlation Coefficient in Cluster Randomized Trials with Binary Outcomes.
Comput Stat Data Anal. 2009 Jan 15;53(3):596-602. doi: 10.1016/j.csda.2008.09.007.
3
A flexible sample size solution for longitudinal and crossover cluster randomized trials with continuous outcomes.
Contemp Clin Trials. 2021 Oct;109:106543. doi: 10.1016/j.cct.2021.106543. Epub 2021 Aug 25.
4
Sample size considerations for stratified cluster randomization design with binary outcomes and varying cluster size.
Stat Med. 2019 Aug 15;38(18):3395-3404. doi: 10.1002/sim.8175. Epub 2019 Apr 29.
5
Incorporating pragmatic features into power analysis for cluster randomized trials with a count outcome.
Stat Med. 2020 Nov 30;39(27):4037-4050. doi: 10.1002/sim.8707. Epub 2020 Aug 10.
7
Sample size estimation for stratified cluster randomization trial with survival endpoint.
Stat Methods Med Res. 2024 May;33(5):838-857. doi: 10.1177/09622802241236953. Epub 2024 Mar 29.
9
Sample size calculation for cluster randomization trials with a time-to-event endpoint.
Stat Med. 2020 Nov 10;39(25):3608-3623. doi: 10.1002/sim.8683. Epub 2020 Jul 30.

引用本文的文献

1
Impact of Destination Image Formation on Tourist Trust: Mediating Role of Tourist Satisfaction.
Front Psychol. 2022 Apr 1;13:845538. doi: 10.3389/fpsyg.2022.845538. eCollection 2022.
2
Methods for dealing with unequal cluster sizes in cluster randomized trials: A scoping review.
PLoS One. 2021 Jul 29;16(7):e0255389. doi: 10.1371/journal.pone.0255389. eCollection 2021.
3
Sample size estimation for modified Poisson analysis of cluster randomized trials with a binary outcome.
Stat Methods Med Res. 2021 May;30(5):1288-1305. doi: 10.1177/0962280221990415. Epub 2021 Apr 7.
4
Sample size and power considerations for cluster randomized trials with count outcomes subject to right truncation.
Biom J. 2021 Jun;63(5):1052-1071. doi: 10.1002/bimj.202000230. Epub 2021 Mar 10.

本文引用的文献

1
Methods for sample size determination in cluster randomized trials.
Int J Epidemiol. 2015 Jun;44(3):1051-67. doi: 10.1093/ije/dyv113. Epub 2015 Jul 13.
2
Sample size determination for clustered count data.
Stat Med. 2013 Oct 30;32(24):4162-79. doi: 10.1002/sim.5819. Epub 2013 Apr 16.
6
Relative efficiency of unequal cluster sizes for variance component estimation in cluster randomized and multicentre trials.
Stat Methods Med Res. 2008 Aug;17(4):439-58. doi: 10.1177/0962280206079018. Epub 2007 Aug 14.
8
Sample size for cluster randomized trials: effect of coefficient of variation of cluster size and analysis method.
Int J Epidemiol. 2006 Oct;35(5):1292-300. doi: 10.1093/ije/dyl129. Epub 2006 Aug 30.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验