Kölmel H W, von Maravic M
Department of Neurology, Free University of Berlin, West Germany.
Acta Neurol Scand. 1988 Jul;78(1):6-9. doi: 10.1111/j.1600-0404.1988.tb03610.x.
The relation between lactate concentration and cell count was determined in 394 CSF samples from unselected patients. In addition, a similar analysis was performed in 156 CSF samples from patients with bacterial and non-bacterial meningitis. The correlation between cell type and lactate level was also examined. The analysis demonstrated a significant linear increase in lactate showing high lactate levels at cell counts above 350 cells per microliter. Since the lactic acid concentration in bacterial meningitis increases linearly with the number of lactate-producing cells, it may be concluded that the increased lactate concentration results from CSF pleocytosis. If lactate levels are higher than the normal distribution, additional sources of lactate production such as cerebral hypoxia must be assumed.
在来自未经挑选患者的394份脑脊液样本中测定了乳酸浓度与细胞计数之间的关系。此外，对来自患有细菌性和非细菌性脑膜炎患者的156份脑脊液样本进行了类似分析。还检查了细胞类型与乳酸水平之间的相关性。分析表明，乳酸呈显著线性增加，在细胞计数高于每微升350个细胞时显示出高乳酸水平。由于细菌性脑膜炎中的乳酸浓度随产乳酸细胞数量呈线性增加，因此可以得出结论，乳酸浓度升高是脑脊液细胞增多所致。如果乳酸水平高于正常分布，则必须假定存在其他乳酸产生来源，如脑缺氧。
