Owen F L, Finnegan A, Gates E R, Gottlieb P D
Eur J Immunol. 1979 Dec;9(12):948-55. doi: 10.1002/eji.1830091208.
An antiserum raised in BALB/c AnN mice against selected CAL.20 T cells reacts with a cell surface antigen in virgin animals that is found on 25% of mature thymocytes and Lyt-2-bearing T cells, but not on prothymocytes, Lyt-1 T cells or B cells. The antigen is restricted to strains carrying the Ig-1d or Ig-1e heavy chain allotype haplotypes. It is expressed in F1 mice. The antiserum blocks the binding of suppressor T cells to the cross-reacting idiotype for arsonate while reagents specific for Fab, Fc or Ig were ineffective. We suggest that the antigen described represents a determinant on the product of a new locus coding for a heavy chain-linked polypeptide found on a subpopulation of T cells.
在BALB/c AnN小鼠中产生的针对选定CAL.20 T细胞的抗血清，能与未成熟动物的一种细胞表面抗原发生反应，该抗原存在于25%的成熟胸腺细胞和携带Lyt-2的T细胞上，但不存在于前胸腺细胞、Lyt-1 T细胞或B细胞上。该抗原仅限于携带Ig-1d或Ig-1e重链同种异型单倍型的品系。它在F1小鼠中表达。该抗血清可阻断抑制性T细胞与砷酸盐交叉反应独特型的结合，而针对Fab、Fc或Ig的试剂则无效。我们认为所描述的抗原代表了一个新基因座产物上的一个决定簇，该基因座编码在T细胞亚群上发现的一种重链连接多肽。
