Chelminiak-Dudkiewicz Dorota
Department of Biomedical Chemistry and Polymer Science, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland.
Int J Mol Sci. 2025 May 31;26(11):5314. doi: 10.3390/ijms26115314.
This study reports on the design and development of novel porous biomaterials based on chitosan, water kefiran, and paramylon, enriched with various concentrations of juniper berry oil (JBO). The materials were obtained by freeze-drying and comprehensively characterized. The analyses included morphological evaluation (SEM and porosity), physicochemical tests (swelling rate, water vapor transmission rate, and roughness), mechanical tests (tensile strength, Young's modulus, and elongation at break), and biodegradability under physiological conditions. Moreover, the functional behavior of the materials was evaluated by assessing their antioxidant and anti-inflammatory activity, as well as interactions with selected proteins (human serum albumin and fibrinogen) relevant to biological responses. It was found that the presence of JBO affects the internal structure and improves selected properties in a concentration-dependent manner. This study is the first to investigate the combined use of chitosan, water kefiran, and paramylon in a single porous system enriched with JBO. The results confirm the importance of such biopolymer sponges as promising platforms for applications where appropriate physicochemical and bioactive properties are desired.
本研究报道了基于壳聚糖、水开菲尔多糖和副淀粉，富含不同浓度杜松子精油（JBO）的新型多孔生物材料的设计与开发。这些材料通过冷冻干燥获得并进行了全面表征。分析包括形态学评估（扫描电子显微镜和孔隙率）、物理化学测试（溶胀率、水蒸气透过率和粗糙度）、力学测试（拉伸强度、杨氏模量和断裂伸长率）以及生理条件下的生物降解性。此外，通过评估材料的抗氧化和抗炎活性以及与生物反应相关的选定蛋白质（人血清白蛋白和纤维蛋白原）的相互作用，对材料的功能行为进行了评估。结果发现，JBO的存在会影响内部结构，并以浓度依赖的方式改善选定的性能。本研究首次探讨了在富含JBO的单一多孔体系中壳聚糖、水开菲尔多糖和副淀粉的联合使用。结果证实了这种生物聚合物海绵作为具有合适物理化学和生物活性特性的有前景的应用平台的重要性。
