Martínez Costa C, García Vila A, Brines Solanes J, Codoñer Franch P
Departamento de Pediatría, Hospital Clínico Universitario, Valencia.
An Esp Pediatr. 1988 May;28(5):425-8.
Therapeutic effects of metronidazole (Flagyl), tinidazole (Tricolam 500) and chlorhydrate of quinacrine in a study of 106 children with symptomatic giardiasis are compared. To evaluate results, cure percentage, efficacy and presence of secondary effects were quantified. Tinidazole was demonstrated most effective drug (96% effective) when compared with quinacrine (83.3% effective) and metronidazole (70.2%) (p less than 0.05). Authors recommend following regime: tinidazole 50-75 mg/kg divided in 2-3 doses, one day; chlorhydrate of quinacrine 6 mg/kg/day divided in 3 doses, five days; metronidazole 15-20 mg/kg/day divided in 3 doses, seven to ten days.
比较了甲硝唑（灭滴灵）、替硝唑（三氯氨唑500）和盐酸阿的平在106例有症状贾第虫病患儿研究中的治疗效果。为评估结果，对治愈率、疗效和副作用的存在情况进行了量化。与阿的平（有效率83.3%）和甲硝唑（70.2%）相比，替硝唑被证明是最有效的药物（有效率96%）（p<0.05）。作者推荐以下治疗方案：替硝唑50 - 75mg/kg，分2 - 3剂，服用1天；盐酸阿的平6mg/kg/天，分3剂，服用5天；甲硝唑15 - 20mg/kg/天，分3剂，服用7至10天。
