Gazder A J, Banerjee M
Curr Med Res Opin. 1977;5(2):164-8. doi: 10.1185/03007997709110159.
One hundred children suffering from symptomatic giardiasis were treated with either tinidazole or metronidazole in random order. Both the drugs were given as a single oral dose calculated on the basis of 50 mg/kg body weight. Parasitological and clinical cure was obtained in 40 (80%) of 50 patients given tinidazole and in 18(36%) of 50 patients given metronidazole. This difference in cure rates was significant (p less than 0.01). Furthermore, control of diarrhoea and negative stool conversion for G. lamblia were achieved earlier with tinidazole than with metronidazole, the differences being significant (p less than 0.01) from the 8th post-treatment day. Gastro-intestinal side-effects of mild degree occurred in 6 patients on tinidazole and in 2 patients on metronidazole; they comprised nausea, vomiting, and bitter taste. Neither drug caused any abnormal deviation in blood counts or in biochemical tests of liver and kidney function.
100名有症状的贾第虫病患儿被随机给予替硝唑或甲硝唑进行治疗。两种药物均按50mg/kg体重计算的单次口服剂量给药。50名接受替硝唑治疗的患者中有40名（80%）获得了寄生虫学和临床治愈，50名接受甲硝唑治疗的患者中有18名（36%）获得治愈。治愈率的这种差异具有显著性（p<0.01）。此外，替硝唑比甲硝唑更早实现腹泻控制和粪类圆线虫粪便转阴，从治疗后第8天起差异具有显著性（p<0.01）。6名接受替硝唑治疗的患者和2名接受甲硝唑治疗的患者出现轻度胃肠道副作用；包括恶心、呕吐和口苦。两种药物均未导致血常规或肝肾功能生化检查出现任何异常偏差。
