Speelman P
Antimicrob Agents Chemother. 1985 Feb;27(2):227-9. doi: 10.1128/AAC.27.2.227.
Sixty-three expatriate residents and travellers in Bangladesh, infected with Giardia lamblia, participated in two studies to compare the therapeutic efficacy of tinidazole and metronidazole. In the first trial 33 randomly selected patients were treated with tinidazole (50 mg/kg of body weight to a maximum of 2 g) or metronidazole (60 mg/kg of body weight to a maximum of 2.4 g) in a single oral dose. Patients were followed for 4 weeks after the end of therapy for the presence of G. lamblia in their stools. Sixteen (94%) of 17 patients receiving tinidazole were free of G. lamblia during that period, compared to only 9 (56%) of 16 patients who had received metronidazole (P less than 0.02). In the second trial patients were randomly allocated to a treatment schedule of either metronidazole as a single dose on 3 successive days (50 mg/kg of body weight to a maximum of 2 g daily) or tinidazole as a single oral dose (50 mg/kg of body weight to a maximum of 2 g). All 15 patients treated with tinidazole and 14 (93%) of 15 patients treated with metronidazole were free of G. lamblia during the 4-week follow-up period. A single oral dose of tinidazole is a highly effective treatment for giardiasis and is equal in efficacy to a 3-day therapy with metronidazole.
63名在孟加拉国感染蓝氏贾第鞭毛虫的外籍居民和旅行者参与了两项研究，以比较替硝唑和甲硝唑的治疗效果。在第一项试验中，33名随机选择的患者接受了替硝唑（50mg/kg体重，最大剂量2g）或甲硝唑（60mg/kg体重，最大剂量2.4g）单次口服治疗。治疗结束后对患者进行4周随访，观察其粪便中是否存在蓝氏贾第鞭毛虫。在此期间，接受替硝唑治疗的17名患者中有16名（94%）粪便中未检出蓝氏贾第鞭毛虫，而接受甲硝唑治疗的16名患者中只有9名（56%）未检出（P<0.02）。在第二项试验中，患者被随机分配到以下治疗方案：连续3天每天单次服用甲硝唑（50mg/kg体重，最大剂量2g/天）或单次口服替硝唑（50mg/kg体重，最大剂量2g）。在4周的随访期内，所有15名接受替硝唑治疗的患者以及15名接受甲硝唑治疗的患者中的14名（93%）粪便中均未检出蓝氏贾第鞭毛虫。单次口服替硝唑是治疗贾第虫病的高效疗法，其疗效与甲硝唑3天疗法相当。
