Cammisuli Davide Maria, Cammisuli Salvatore Massimiliano, Fusi Jonathan, Franzoni Ferdinando, Pruneti Carlo
Laboratories of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
School of Medicine, University of Pisa, Pisa, Italy.
Front Aging Neurosci. 2019 Nov 8;11:303. doi: 10.3389/fnagi.2019.00303. eCollection 2019.
Mild cognitive impairment (MCI) is a common feature in Parkinson's Disease (PD), even at the time of diagnosis. Some levels of heterogeneity in nature and severity of cognitive impairment and risk of conversion to Parkinson's Disease Dementia (PDD) exist. This brief overview summarized the current understanding of MCI in PD, by considering the following major points: historical development of the clinical entity, evaluation, epidemiology, predictors and outcomes, neuroimaging findings, pathophysiology, treatment, and pharmacological and non-pharmacological intervention. MCI in PD represents a concept in evolution and plays a pivotal role in advancing our understanding of the disease mechanisms, with the ultimate goal of building effective strategies to prevent conversion into PDD. Challenges for future research are also discussed.
轻度认知障碍（MCI）是帕金森病（PD）的常见特征，甚至在诊断时就已存在。认知障碍的性质、严重程度以及转化为帕金森病痴呆（PDD）的风险存在一定程度的异质性。本简要概述通过考虑以下要点总结了目前对PD中MCI的理解：该临床实体的历史发展、评估、流行病学、预测因素和结局、神经影像学发现、病理生理学、治疗以及药物和非药物干预。PD中的MCI代表了一个不断演变的概念，在推进我们对疾病机制的理解方面发挥着关键作用，最终目标是建立有效的策略来预防转化为PDD。还讨论了未来研究面临的挑战。
