Pearson A D, Reid M M, Davison E V, Bown N, Malcolm A J, Craft A W
Department of Child Health, University of Newcastle upon Tyne.
Arch Dis Child. 1988 Sep;63(9):1012-5. doi: 10.1136/adc.63.9.1012.
The association of non-random chromosome abnormalities with solid tumours of childhood may improve accuracy of diagnosis and prognosis and lead to a better understanding of their biology. In a pilot study in the Northern region of England fresh tumour biopsy specimens were obtained from 39 to 72 consecutive solid tumours in children who presented over a period of 21 months. Cytogenetic analysis was possible in 33 and clonal chromosomal abnormalities were detected in nine. In addition, seven of 10 tumours investigated after treatment were abnormal. Ten of these 16 abnormal karyotypes have not previously been described. This pilot study has shown that a concerted investigation of tumour cytogenetics is possible. A multicentre study is essential if our knowledge of basic tumour cytogenetics is to progress.
非随机染色体异常与儿童实体瘤的关联可能会提高诊断和预后的准确性，并有助于更好地理解其生物学特性。在英格兰北部地区的一项试点研究中，从21个月内连续收治的39至72例儿童实体瘤患者中获取了新鲜肿瘤活检标本。33例标本可行细胞遗传学分析，其中9例检测到克隆性染色体异常。此外，治疗后检测的10例肿瘤中有7例异常。这16种异常核型中有10种此前未曾有过描述。这项试点研究表明，对肿瘤细胞遗传学进行协同研究是可行的。如果我们要在基础肿瘤细胞遗传学知识方面取得进展，多中心研究至关重要。
