Bouteille B, Darde M L, Dumas M, Catanzano G, Pestre-Alexandre M, Breton J C, Nicolas A, N'Do D C
Service de Parasitologie, Faculté de Médecine, Limoges, France.
Ann Trop Med Parasitol. 1988 Apr;82(2):141-8. doi: 10.1080/00034983.1988.11812221.
Sheep were used as an experimental model to study trypanosomiasis. Twelve animals were infected with Trypanosoma brucei brucei, and the clinical evolution of the disease in the sheep corresponded closely to that described in human patients. The main clinical signs of the experimental infection were hyperthermia, anaemia, loss of weight and behavioural disturbances. Death occurred in all cases after a mean time of 75 days. Trypanosomes were detected in blood films nine to 15 days after inoculation, and the parasitaemia was usually mild and irregular. Changes in the cerebrospinal fluid--increase in leucocyte counts and the presence of trypanosomes--appeared after about 45 days. This model would provide a valuable way of testing the effectiveness of new therapeutic drugs.
绵羊被用作研究锥虫病的实验模型。12只动物感染了布氏布氏锥虫，绵羊疾病的临床演变与人类患者中描述的情况密切相符。实验性感染的主要临床症状为高热、贫血、体重减轻和行为紊乱。所有病例均在平均75天后死亡。接种后9至15天在血片中检测到锥虫，寄生虫血症通常较轻且不规则。大约45天后出现脑脊液变化——白细胞计数增加和锥虫存在。该模型将为测试新治疗药物的有效性提供一种有价值的方法。
