Key Laboratory of Smart Drug Delivery, School of Pharmacy, Fudan University, Ministry of Education, 826 Zhangheng Road, Shanghai 201203, China.
Department of Biomedical Engineering, Columbia University Medical Center, 3960 Broadway, New York, NY 10032, USA.
Biomolecules. 2019 Nov 27;9(12):790. doi: 10.3390/biom9120790.
Human neuroscience has made remarkable progress in understanding basic aspects of functional organization; it is a renowned fact that the blood-brain barrier (BBB) impedes the permeation and access of most drugs to central nervous system (CNS) and that many neurological diseases remain undertreated. Therefore, a number of nanocarriers have been designed over the past few decades to deliver drugs to the brain. Among these nanomaterials, dendrimers have procured an enormous attention from scholars because of their nanoscale uniform size, ease of multi-functionalization, and available internal cavities. As hyper-branched 3D macromolecules, dendrimers can be maneuvered to transport diverse therapeutic agents, incorporating small molecules, peptides, and genes; diminishing their cytotoxicity; and improving their efficacy. Herein, the present review will give exhaustive details of extensive researches in the field of dendrimer-based vehicles to deliver drugs through the BBB in a secure and effectual manner. It is also a souvenir in commemorating Donald A. Tomalia on his 80th birthday.
人类神经科学在理解功能组织的基本方面取得了显著进展；众所周知，血脑屏障（BBB）阻碍了大多数药物向中枢神经系统（CNS）的渗透和进入，许多神经疾病仍然治疗不足。因此，在过去几十年中，已经设计了许多纳米载体将药物递送到大脑。在这些纳米材料中，由于其纳米级均匀尺寸、易于多功能化和可用的内部空腔，树枝状聚合物引起了学者们的极大关注。作为超支化的 3D 大分子，树枝状聚合物可以被操纵来运输各种治疗剂，包括小分子、肽和基因；降低其细胞毒性；并提高其功效。本文综述详尽地介绍了基于树枝状聚合物的载体在安全有效地通过 BBB 递药方面的广泛研究。这也是对唐纳德·A·托马利亚 80 岁生日的纪念。
