Institute for Innovation & Sustainable Development in Food Chain, Public University of Navarre, Jeronimo de Ayanz Building, Campus de Arrosadia, 31006 Pamplona, Spain.
TECNALIA, Parque Tecnológico de Álava, Leonardo Da Vinci, 11, 01510 Miñano, Spain.
Nutrients. 2019 Nov 27;11(12):2890. doi: 10.3390/nu11122890.
Early detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142-3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.
早期发现儿童肥胖及其相关合并症需要优先考虑制定有效的治疗干预措施。循环 microRNAs（miRNAs）已被提议作为肥胖及其合并症的生物标志物；因此，我们进行了一项系统综述，以总结已定量检测肥胖儿童和青少年中 miRNA 谱的研究结果，以及肥胖和/或相关疾病的儿童。本综述纳入了 9 项旨在检查正常体重儿童与肥胖儿童之间或肥胖儿童与无心血管代谢疾病之间 miRNA 表达水平差异的研究。我们确定了四种在肥胖中过度表达的 miRNA（miR-222、miR-142-3、miR-140-5p 和 miR-143）和两种在肥胖和非酒精性脂肪性肝病（NAFLD）和/或胰岛素抵抗的儿童中过度表达的 miRNA（miR-122 和 miR-34a）。总之，循环 miRNAs 是肥胖相关疾病（如非酒精性脂肪性肝病和 2 型糖尿病）的有前途的诊断生物标志物，即使在儿童中也是如此。然而，需要更多的儿童研究，使用大规模搜索技术和更大的样本量，以得出任何确凿的结论。
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