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阿苯达唑在血清、脑脊液和脑包虫囊肿中的浓度。

Concentrations of albendazole in serum, cerebrospinal fluid and hydatidous brain cyst.

作者信息

Moskopp D, Lotterer E

机构信息

Neurosurgical Department, University of Münster, Fed. Rep. of Germany.

出版信息

Neurosurg Rev. 1993;16(1):35-7. doi: 10.1007/BF00308610.

DOI:10.1007/BF00308610
PMID:8483517
Abstract

A young girl with cerebral echinococcosis was treated with albendazole (13 mg/kg/d, p.o.). The concentrations of albendazole sulphoxide were determined in serum, cerebrospinal fluid and hydatidous cyst over a month. The mean ratios of concentration were: CSF/serum = 50%, cyst/serum = 40%, cyst/CSF = 80%.

摘要

一名患有脑包虫病的年轻女孩接受了阿苯达唑治疗(13毫克/千克/天,口服)。在一个多月的时间里测定了血清、脑脊液和包虫囊肿中阿苯达唑亚砜的浓度。浓度的平均比值为:脑脊液/血清 = 50%,囊肿/血清 = 40%,囊肿/脑脊液 = 80%。

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本文引用的文献

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Albendazole therapy for neurocysticercosis.阿苯达唑治疗神经囊尾蚴病。
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Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents.某些抗菌药物诱导多药耐药基因后,唑类药物对白色念珠菌活性的拮抗作用。
Antimicrob Agents Chemother. 1999 Aug;43(8):1968-74. doi: 10.1128/AAC.43.8.1968.
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Multiple hydatid cysts of the brain: a case report and review of the literature.脑内多发包虫囊肿:一例报告并文献复习
Neurosurg Rev. 1998;21(2-3):181-4. doi: 10.1007/BF02389329.
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[Chemotherapy of alveolar echinococcosis with benzimidazoles. A prospective long-term study].[苯并咪唑类药物治疗肺泡型棘球蚴病的前瞻性长期研究]
Med Klin (Munich). 1998 Aug 15;93(8):463-7. doi: 10.1007/BF03042595.
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Albendazole treatment of human cystic echinococcosis.阿苯达唑治疗人体囊型包虫病。
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Short course of albendazole therapy for neurocysticercosis.阿苯达唑短程疗法治疗神经囊尾蚴病
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Neurocysticercosis: treatment with albendazole and dextrochloropheniramine (preliminary report).神经囊尾蚴病:阿苯达唑与右氯苯那敏联合治疗(初步报告)
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Sensitive high-performance liquid chromatographic assay for albendazole and its main metabolite albendazole sulphoxide in plasma and cerebrospinal fluid.血浆和脑脊液中阿苯达唑及其主要代谢物阿苯达唑亚砜的灵敏高效液相色谱测定法。
J Chromatogr. 1989 Sep 29;494:403-7. doi: 10.1016/s0378-4347(00)82695-x.
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Neurocysticercosis: treatment with albendazole.神经囊尾蚴病:阿苯达唑治疗
Trans R Soc Trop Med Hyg. 1990 Jan-Feb;84(1):174. doi: 10.1016/0035-9203(90)90421-a.
10
Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis.神经囊尾蚴病患者血浆和脑脊液中阿苯达唑及吡喹酮的水平
Clin Neuropharmacol. 1990 Dec;13(6):559-64. doi: 10.1097/00002826-199012000-00008.