Mahidol-Osaka Center for Infectious Diseases, Mahidol University, Bangkok, Thailand.
Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Infect Genet Evol. 2020 Mar;78:104129. doi: 10.1016/j.meegid.2019.104129. Epub 2019 Nov 28.
Chikungunya virus (CHIKV), a positive-sense, single-stranded RNA virus in the family Togaviridae, is transmitted by Aedes mosquitoes. Of three known CHIKV genotypes, the Asian genotype was introduced into the Caribbean islands and rapidly spread throughout Central and South Americas. We previously found patients with symptoms compatible with chikungunya fever in 2014-2015 in Aruba, a Caribbean island of 180 km. We here describe the full genome sequences of eight CHIKV strains isolated from patient sera of the Aruban outbreak. Phylogenetic analysis revealed that two closely related but distinct lineages of Asian-genotype CHIKV circulated simultaneously during the epidemic in 2014-2015. These results suggested that CHIKV was introduced into Aruba more than once in a short period, reflecting the importance of Aruba as a travel hub within the region.
基孔肯雅热病毒（CHIKV）属于披膜病毒科甲病毒属，为正链单股 RNA 病毒，通过伊蚊传播。已知的 CHIKV 有 3 种基因型，其中亚洲基因型传入加勒比海岛屿后迅速传播至中美洲和南美洲。我们曾于 2014-2015 年在阿鲁巴岛（加勒比海 180 公里的一个岛屿）发现与基孔肯雅热症状相符的患者。在此，我们描述了从阿鲁巴岛疫情患者血清中分离的 8 株 CHIKV 毒株的全基因组序列。系统进化分析显示，在 2014-2015 年的流行期间，同时存在两种密切相关但不同的亚洲基因型 CHIKV 谱系。这些结果表明，在短时间内 CHIKV 多次传入阿鲁巴岛，这反映了阿鲁巴岛作为该地区旅行枢纽的重要性。
