Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University and National Health Research Institutes, Taipei, Taiwan.
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan.
J Biomed Sci. 2019 Dec 2;26(1):94. doi: 10.1186/s12929-019-0587-9.
Insulin-like growth factor 1 (IGF-1) is an important pleiotropic hormone that exerts neuroprotective and neuroreparative effects after a brain injury. However, the roles of IGF-1 variants in mild traumatic brain injury (mTBI) are not yet fully understood. This study attempted to elucidate the effects of IGF-1 variants on the risk and neuropsychiatric outcomes of mTBI.
Based on 176 recruited mTBI patients and 1517 control subjects from the Taiwan Biobank project, we first compared the genotypic distributions of IGF-1 variants between the two groups. Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances. Functional annotation of IGF-1 variants was also performed through bioinformatics databases.
The minor allele of rs7136446 was over-represented in mTBI patients compared to community-based control subjects. Patients carrying minor alleles of rs7136446 and rs972936 showed more dizziness and multiple neuropsychiatric symptoms after brain injury.
IGF-1 variants were associated with the risk and neuropsychiatric symptoms of mTBI. The findings highlight the important role of IGF-1 in the susceptibility and clinical outcomes of mTBI.
胰岛素样生长因子 1（IGF-1）是一种重要的多效激素，在脑损伤后具有神经保护和神经修复作用。然而，IGF-1 变体在轻度创伤性脑损伤（mTBI）中的作用尚不完全清楚。本研究试图阐明 IGF-1 变体对 mTBI 风险和神经精神结局的影响。
基于来自台湾生物银行计划的 176 名 mTBI 患者和 1517 名对照，我们首先比较了两组之间 IGF-1 变体的基因型分布。然后，我们分析了 IGF-1 变体与 mTBI 后神经精神症状之间的关联，包括焦虑、抑郁、头晕和睡眠障碍。通过生物信息学数据库还对 IGF-1 变体进行了功能注释。
与基于社区的对照组相比，rs7136446 的次要等位基因在 mTBI 患者中过度表达。携带 rs7136446 和 rs972936 次要等位基因的患者在脑损伤后出现更多的头晕和多种神经精神症状。
IGF-1 变体与 mTBI 的风险和神经精神症状相关。这些发现强调了 IGF-1 在 mTBI 易感性和临床结局中的重要作用。
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