Ren Ping, Hu Meiling
Department of Medicine, The Affiliated Hospital of Ningbo University School of Medicine, Ningbo, Zhejiang 315020, P.R. China.
Department of Surgery, Cixi People's Hospital of Zhejiang, Ningbo, Zhejiang 315300, P.R. China.
Oncol Lett. 2019 Dec;18(6):6164-6170. doi: 10.3892/ol.2019.10990. Epub 2019 Oct 14.
The prognostic significance of long non-coding RNAs (lncRNAs) in Wilms' tumor (WT) remains unclear. The present study identified differential lncRNA expression patterns between WT and normal tissues; and evaluated the prognostic value of these lncRNAs. Multidimensional data from 136 samples were retrieved from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database. Computational data analyses were performed to detect survival-associated molecular signatures. Kaplan-Meier survival curves revealed the prognostic prediction values for three of these lncRNAs, namely DLGAP1 antisense RNA 2 (DLGAP1-AS2), RP11-93B14.6 and RP11554F20.1. Cox regression analysis revealed that the three-lncRNA signature was significantly associated with patient survival (P<0.01). Functional enrichment analyses suggested that the target genes of these three lncRNAs may be involved in known cancer-associated pathways. The present study revealed a three-lncRNA signature consisting of DLGAP1-AS2, RP11-93B14.6 and RP11554F20.1 that may be used as a prognostic marker for patients with WT.
长链非编码RNA（lncRNA）在肾母细胞瘤（WT）中的预后意义仍不清楚。本研究确定了WT组织与正常组织之间lncRNA的差异表达模式；并评估了这些lncRNA的预后价值。从治疗应用研究以产生有效治疗方法（TARGET）数据库中检索了136个样本的多维数据。进行了计算数据分析以检测与生存相关的分子特征。Kaplan-Meier生存曲线揭示了其中三种lncRNA的预后预测价值，即DLGAP1反义RNA 2（DLGAP1-AS2）、RP11-93B14.6和RP11554F20.1。Cox回归分析显示，这三种lncRNA特征与患者生存显著相关（P<0.01）。功能富集分析表明，这三种lncRNA的靶基因可能参与已知的癌症相关途径。本研究揭示了一种由DLGAP1-AS2、RP11-93B14.6和RP11554F20.1组成的三种lncRNA特征，可作为WT患者的预后标志物。
