卡托苷增强骨髓间充质干细胞来源外泌体在软骨修复中的治疗效果。
Kartogenin enhances the therapeutic effect of bone marrow mesenchymal stem cells derived exosomes in cartilage repair.
机构信息
Institute of Biomedical & Pharmaceutical Technology, Fuzhou University, Fuzhou 350002, PR China.
College of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, PR China.
出版信息
Nanomedicine (Lond). 2020 Feb;15(3):273-288. doi: 10.2217/nnm-2019-0208. Epub 2019 Dec 2.
The effectiveness of mesenchymal stem cells (MSC) in the treatment of cartilage diseases has been demonstrated to be attributed to the paracrine mechanisms, especially the mediation of exosomes. But the exosomes derived from unsynchronized MSCs may be nonhomogeneous and the therapeutic effect varies between samples. To produce homogeneous and more effective exosomes for the regeneration of cartilage. In this study we produced specific exosomes from bone marrow MSCs (BMSC) through kartogenin (KGN) preconditioning and investigated their performance in either or experiments. The exosomes derived from KGN-preconditioned BMSCs (KGN-BMSC-Exos) performed more effectively than the exosomes derived from BMSCs (BMSC-Exos). KGN preconditioning endowed BMSC-Exos with stronger chondral matrix formation and less degradation.
间充质干细胞（MSC）在治疗软骨疾病方面的有效性归因于旁分泌机制，特别是外泌体的介导。但是，来自未同步 MSC 的外泌体可能不均匀，并且样品之间的治疗效果也不同。为了产生用于软骨再生的同质且更有效的外泌体。在这项研究中，我们通过卡托金（KGN）预处理从骨髓间充质干细胞（BMSC）中产生了特定的外泌体，并研究了它们在或实验中的性能。来自 KGN 预处理的 BMSC（KGN-BMSC-Exos）的外泌体比来自 BMSC（BMSC-Exos）的外泌体更有效。KGN 预处理使 BMSC-Exos 具有更强的软骨基质形成能力和更少的降解。
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