Feng Nicole C, Ryan Eliza, Kidane Mhretab, Tusch Erich S, McFeeley Brittany M, Carlsson Roger, Mohammed Abdul H, Håkansson Krister, Daffner Kirk R
Department of Neurology, Center for Brain/Mind Medicine, Brigham and Women's Hospital, Harvard Medical School, Hale Building for Transformative Medicine, Boston, MA, USA.
Department of Computer Science and Media Technology, Linnaeus University, Växjö, Sweden.
Alzheimers Dement (N Y). 2019 Nov 22;5:825-833. doi: 10.1016/j.trci.2019.10.005. eCollection 2019.
Increased physical exercise is linked to enhanced brain health and reduced dementia risk. Exercise intervention studies usually are conducted at facilities in groups under trainer supervision. To improve scalability, accessibility, and engagement, programs may need to be structured such that individuals can execute and adjust routines in their own homes.
One hundred eighty-three healthy older adults from two sites (the United States and Sweden) were screened. One hundred fifty-six subjects (mean age 73.2), randomly assigned to one of four interventions (PACE-Yourself physical exercise program, mindfulness meditation, or Cogmed® adaptive or nonadaptive computerized working memory training) began the study. All interventions were structurally similar: occurring in subjects' homes using interactive, web-based software, over five weeks, ∼175 minutes/week. In the PACE-Yourself program, video segments presented aerobic exercises at different pace and intensity (P&I). The program paused frequently, allowing subjects to indicate whether P&I was "too easy," "too hard," or "somewhat hard." P&I of the subsequent exercise set was adjusted, allowing subjects to exercise at a perceived exertion level of "somewhat hard." Program completion was defined as finishing ≥60% of sessions.
A high percentage of participants in all groups completed the program, although the number (86%) was slightly lower in the PACE-Yourself group than the other three. Excluding dropouts, the PACE-Yourself group had a lower adherence rate of 93%, compared with the other three (∼98%). Over the five weeks, PACE-Yourself participants increased exercising at the highest intensity level, consistent with augmented aerobic activity over time. The number of exercise sessions completed predicted the postintervention versus preintervention increase in self-reported level of physical activity.
This study supports the feasibility of a home-based, subject-controlled, exercise program in which P&I is regulated via real-time participant feedback, which may promote self-efficacy. Further study is needed to determine if similar results are found over longer periods and in more diverse populations.
增加体育锻炼与改善大脑健康和降低痴呆风险相关。运动干预研究通常在设施场所中,在教练监督下以小组形式进行。为了提高可扩展性、可及性和参与度,项目可能需要进行结构化设计,以便个人能够在自己家中执行和调整日常锻炼。
对来自两个地点(美国和瑞典)的183名健康老年人进行了筛查。156名受试者(平均年龄73.2岁)被随机分配到四种干预措施之一(“掌控自己节奏”体育锻炼项目、正念冥想、或Cogmed®适应性或非适应性计算机化工作记忆训练)后开始研究。所有干预措施在结构上相似:在受试者家中使用交互式网络软件进行,为期五周,每周约175分钟。在“掌控自己节奏”项目中,视频片段展示了不同节奏和强度(节奏和强度)的有氧运动。该项目经常暂停,让受试者表明节奏和强度是“太容易”、“太难”还是“有点难”。随后锻炼组的节奏和强度会进行调整,使受试者能够以“有点难”的自觉用力程度进行锻炼。项目完成定义为完成≥60%的课程。
所有组中都有很高比例的参与者完成了项目,尽管“掌控自己节奏”组的这一比例(86%)略低于其他三组。排除退出者后,“掌控自己节奏”组的依从率为93%,低于其他三组(约98%)。在五周时间里,“掌控自己节奏”项目的参与者在最高强度水平上增加了锻炼,这与随着时间推移有氧活动的增加一致。完成的锻炼课程数量预测了干预后与干预前自我报告的身体活动水平的增加。
本研究支持了一种基于家庭、由受试者控制的锻炼项目的可行性,该项目通过实时参与者反馈来调节节奏和强度,这可能会提高自我效能感。需要进一步研究以确定在更长时间和更多样化人群中是否能得到类似结果。