基于应用程序的便携肺功能仪在青少年哮喘中的验证。
Validation of an app-based portable spirometer in adolescents with asthma.
机构信息
Center for Environmental Medicine, Asthma, & Lung Biology, The University of North Carolina, Chapel Hill, Raleigh, NC, USA.
Department of Kinesiology, University of North Carolina, Charlotte, NC, USA.
出版信息
J Asthma. 2021 Apr;58(4):497-504. doi: 10.1080/02770903.2019.1702201. Epub 2019 Dec 10.
OBJECTIVES
Objective measurements of asthma impairment could aid teens in recognition of changes in asthma status over time. Ready access to a conventional spirometer is not realistic outside of the clinical setting. In this proof-of-concept study, we compared the performance of the VitalFlo mobile spirometer to the nSpire KoKo® sx1000 spirometer for accuracy in measuring Forced Expiratory Volume in one second (FEV) and Forced Vital Capacity (FVC) in adolescents with asthma.
METHODS
Two hundred forty pulmonary function measurements were collected from 48 adolescents with persistent asthma from the University of North Carolina's pediatric allergy and pulmonology subspecialty clinics. Participants performed spirometry with the nSpireKoKo® sx1000 spirometer and the VitalFlo spirometer during their clinic visits. 119 simulated FVC maneuvers were conducted on both devices to standardize measurements. Pearson correlations, Bland-Altman procedure, and two-sample comparison tests were performed to assess the relationship between the two spirometers.
RESULTS
VitalFlo measurements were significantly highly correlated with nSpireKoKo® spirometer values for FEV (=0.721, [95% CI, 0.749 ± 0.120], < 0.001) and moderately for FVC (= 0.617, [95% CI, 0.640 ± 0.130], < 0.001) measurements. There were no statistically significant differences of the mean FEV ( = 0.00764, SD = 0.364, t(59)=0.16, = 0.87) and FVC measurements ( = 0.00261, SD = 0.565, t(59)=0.036, = 0.97.) between the VitalFlo and nSpireKoKo® systems. Both devices demonstrated significantly high correlation when comparing the automated FVC ( = 0.997, [95% CI, 1.00 ± 0.00974], < 0.001) measurements. Bland-Altman plots did not demonstrate significant bias between devices for both FEV (0.00764 L) and FVC (0.00261 L) measurements.
CONCLUSIONS
Lung function measurements from the VitalFlo mobile spirometer were comparable to a commercially-available spirometer commonly used in clinical settings. This validated app-based spirometer for home use has the potential to improve asthma self-management.
目的
客观的哮喘评估可帮助青少年及时识别哮喘状态的变化。除临床环境外，常规肺活量计无法随时获得。在这项概念验证研究中，我们比较了 VitalFlo 移动肺活量计与 nSpire KoKo® sx1000 肺活量计在测量青少年哮喘患者的一秒用力呼气量（FEV）和用力肺活量（FVC）方面的准确性。
方法
来自北卡罗来纳大学儿科过敏和肺病专科诊所的 48 名持续性哮喘青少年进行了 240 次肺功能测量。参与者在就诊时使用 nSpire KoKo® sx1000 肺活量计和 VitalFlo 肺活量计进行肺活量测定。在这两种设备上进行了 119 次模拟 FVC 操作，以标准化测量。采用 Pearson 相关、Bland-Altman 程序和两样本比较检验评估两种肺活量计之间的关系。
结果
VitalFlo 测量值与 nSpire KoKo®肺活量计的 FEV 值高度相关（=0.721，[95%CI，0.749±0.120]，<0.001），与 FVC 值中度相关（=0.617，[95%CI，0.640±0.130]，<0.001）。两种设备测量的平均 FEV（=0.00764，SD=0.364，t（59）=0.16，=0.87）和 FVC（=0.00261，SD=0.565，t（59）=0.036，=0.97）测量值无统计学差异。两种设备的自动 FVC（=0.997，[95%CI，1.00±0.00974]，<0.001）测量值具有高度相关性。Bland-Altman 图显示两种设备之间 FEV（0.00764L）和 FVC（0.00261L）测量值无显著偏差。
结论
VitalFlo 移动肺活量计的肺功能测量值与临床常用的商业肺活量计相当。这种经过验证的基于应用程序的家庭使用肺活量计有可能改善哮喘的自我管理。
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