Reahal S, Wrigglesworth J
Division of Biomolecular Sciences, King's College London, England.
Drug Metab Dispos. 1992 May-Jun;20(3):423-7.
Daily oral or ip administration of coenzyme Q10 to rats for time periods of 2 to 10 weeks leads to its accumulation in liver, concentrating in the soluble fraction of the liver cells. No uptake of coenzyme Q10 can be detected in the heart or kidney. Intraperitoneal administration also results in the accumulation of coenzyme Q10 in the spleen. It is concluded that the normal endogenous levels of quinone in the rat heart and kidney cannot be supplemented over the long term by administration of exogenous quinone.
对大鼠每日口服或腹腔注射辅酶Q10，持续2至10周，会导致其在肝脏中蓄积，并集中在肝细胞的可溶性部分。在心脏或肾脏中未检测到辅酶Q10的摄取。腹腔注射也会导致辅酶Q10在脾脏中蓄积。得出的结论是，长期给予外源性醌不能补充大鼠心脏和肾脏中醌的正常内源性水平。
