Li Juanjuan, Lv Lin, Zhang Jiaqi, Xu Lin, Zeng Enjin, Zhang Zedan, Wang Fengyun, Tang Xudong
Beijing University of Chinese Medicine, Beijing 100029, China.
Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
Evid Based Complement Alternat Med. 2019 Nov 14;2019:7654947. doi: 10.1155/2019/7654947. eCollection 2019.
A combination of peppermint oil and caraway oil (POCO) with its unique properties has been shown clinical benefits for FD. However, the potent statistical data to confirm its effects are lacking. This meta-analysis thus aimed at evaluating the efficacy and safety of POCO compared with placebo in treating patients with FD. We searched CENTRAL, PubMed, EMBASE (Ovid), Web of Science, Google Scholar, China National Knowledge Infrastructure database, Wanfang, and VIP databases for randomized clinical trials (RCTs) up to June 2019. Dichotomous data were shown as a risk ratio (RR) with 95% confidence intervals (CIs). All data were analyzed by Review Manager 5.2 software. The search identified 382 citations, and 5 RCTs (578 participants) were included. POCO showed a statistically significant effect in global improvement of FD symptoms (RR for not much or very much improvement 0.59, 95% CI: 0.49 to 0.71, < 0.00001, 36%, NNT 3) and improvement in epigastric pain (RR 1.61, 95% CI: 1.28 to 2.03, < 0.0001, 0%, NNT 3). There were no significant differences in the total number of adverse events between POCO and placebo (NNH 40). In conclusion, this is the first meta-analysis to assess the effects of POCO in FD. POCO is an effective and safe short-term treatment for FD. However, current findings are based on smaller sample sizes and low/very low quality of the evidence. More well-designed RCTs with large sample sizes of FD patients are required.
薄荷油和葛缕子油组合（POCO）因其独特特性已显示出对功能性消化不良（FD）的临床益处。然而，缺乏确凿的统计数据来证实其效果。因此，本荟萃分析旨在评估POCO与安慰剂相比治疗FD患者的疗效和安全性。我们检索了CENTRAL、PubMed、EMBASE（Ovid）、Web of Science、谷歌学术、中国知网数据库、万方数据库和维普数据库，以查找截至2019年6月的随机临床试验（RCT）。二分数据以风险比（RR）及95%置信区间（CI）表示。所有数据均采用Review Manager 5.2软件进行分析。检索共识别出382条文献，纳入了5项RCT（578名参与者）。POCO在FD症状的总体改善方面显示出统计学显著效果（改善不多或改善很大的RR为0.59，95%CI：0.49至0.71，P<0.00001，I²=36%，NNT=3）以及上腹部疼痛的改善（RR 1.61，95%CI：1.28至2.03，P<0.0001，I²=0%，NNT=3）。POCO与安慰剂之间的不良事件总数无显著差异（NNH=40）。总之，这是第一项评估POCO对FD疗效的荟萃分析。POCO是一种治疗FD的有效且安全的短期疗法。然而，目前的研究结果基于较小的样本量以及低/极低质量的证据。需要更多针对FD患者大样本量的设计良好的RCT。
