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用于局部给药的植物药——一种战略干预措施。

: A phytomedicine for local drug delivery - A strategic intervention.

作者信息

Shivaprasad B M, Patil Padmavati, Nair Sruthi K, Singh Navnita, Shivanand Shilpa, Sameera Ume

机构信息

Department of Periodontology, Raja Rajeswari Dental College and Hospital, Bengaluru, Karnataka, India.

出版信息

Ayu. 2019 Jan-Mar;40(1):53-57. doi: 10.4103/ayu.AYU_40_17.

DOI:10.4103/ayu.AYU_40_17
PMID:31831970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6891999/
Abstract

BACKGROUND

In the Indian system of medicine (ISM) is one of the oldest and longest used natural herbal remedy which consist of mixture of equal parts of the Gaertn. (Family- Euphorbiaceae), Retz. (Family- Combretaceae) and Terminalia beleria [Gaertn.] Roxb. (Family- Combretaceae). Currently, is being extensively researched for its various therapeutic effects including its anti-caries, antioxidant, anti-collagenase and anti-microbial activities. This fruit extract is used in various forms in the treatment of periodontitis.

AIM

The aim of the present study was to compare the clinical and microbiological benefits of routine scaling and root planing (SRP) with adjunctive use of (Hiora GA) as local drug delivery agent in the management of periodontitis.

MATERIALS AND METHODS

Thirteen patients diagnosed with chronic periodontitis were included in the present study. The control sites received SRP alone and the test sites received SRP with locally delivered (Hiora GA). The clinical parameters were evaluated at baseline, 15 days and 1 month. The plaque samples were cultured anaerobically for the keystone-periodontal pathogen , and . The Mann-Whitney U-test and Wilcoxon signed-rank tests were performed to compare the results between the test and control groups.

RESULTS

Statistically significant improvement was observed in both groups. Intergroup comparison of prevalence of microorganisms also revealed a statistically significant difference ( = 0.0007) at 15 days and 1 month.

CONCLUSION

Subgingivally delivered (Hiora GA) as an adjunct to SRP in the treatment of chronic periodontitis has shown anticipative results revealing slow and constant releasing property of .

摘要

背景

在印度医学体系中，[某种草药混合物名称]是最古老且使用时间最长的天然草药疗法之一，它由[大戟科某种植物名称]（大戟科）、[使君子科某种植物名称]（使君子科）和毛诃子[Gaertn.] Roxb.（使君子科）等量混合而成。目前，人们正在对其各种治疗效果进行广泛研究，包括抗龋齿、抗氧化、抗胶原酶和抗菌活性。这种水果提取物以多种形式用于治疗牙周炎。

目的

本研究的目的是比较常规龈上洁治和根面平整（SRP）联合使用[某种草药提取物名称]（Hiora GA）作为局部给药剂在牙周炎治疗中的临床和微生物学益处。

材料与方法

本研究纳入了13例诊断为慢性牙周炎的患者。对照部位仅接受SRP，试验部位接受SRP并局部应用[某种草药提取物名称]（Hiora GA）。在基线、15天和1个月时评估临床参数。对菌斑样本进行厌氧培养，检测关键牙周病原体[病原体名称1]、[病原体名称2]和[病原体名称3]。采用Mann-Whitney U检验和Wilcoxon符号秩检验比较试验组和对照组的结果。

结果

两组均观察到有统计学意义的改善。微生物患病率的组间比较在15天和1个月时也显示出统计学显著差异（P = 0.0007）。

结论

龈下应用[某种草药提取物名称]（Hiora GA）作为SRP治疗慢性牙周炎的辅助手段已显示出预期效果，揭示了[某种草药提取物名称]的缓慢持续释放特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/92bd67df0e5c/AYU-40-53-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/e81c6545fd49/AYU-40-53-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/b6497b6c9b71/AYU-40-53-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/d961f87a8a2e/AYU-40-53-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/92bd67df0e5c/AYU-40-53-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/e81c6545fd49/AYU-40-53-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/b6497b6c9b71/AYU-40-53-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/d961f87a8a2e/AYU-40-53-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9914/6891999/92bd67df0e5c/AYU-40-53-g004.jpg

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本文引用的文献

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Role of triphala in the management of peridontal disease.三果木在牙周疾病管理中的作用。
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Exploring of Antimicrobial Activity of Triphala Mashi-an Ayurvedic Formulation.探索 Triphala Mashi 这种阿育吠陀制剂的抗菌活性。
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Evaluation of the inhibitory effect of triphala on PMN-type matrix metalloproteinase (MMP-9).诃子对中性粒细胞型基质金属蛋白酶（MMP - 9）抑制作用的评估。
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