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由肼屈嗪引起的药物性自身免疫性肝炎导致急性肝衰竭及肝移植

Drug-Induced Autoimmune Hepatitis From Hydralazine Leading to Acute Liver Failure and Liver Transplantation.

作者信息

Grewal Jasleen, Doan Angela, Hong Annie S, Amin Arpit, Scapa Jason V, Hanna Ramy, Durazo Francisco, Yanny Beshoy

机构信息

Department of Medicine, University of California at Los Angeles, Los Angeles, CA.

Department of Medicine, University of Nevada Las Vegas, Las Vegas, NV.

出版信息

ACG Case Rep J. 2019 Oct 23;6(10):e00252. doi: 10.14309/crj.0000000000000252. eCollection 2019 Oct.

DOI:10.14309/crj.0000000000000252
PMID:31832473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6855536/
Abstract

We describe a woman with no previous liver disease who developed drug-induced autoimmune hepatitis from hydralazine prescribed to her for hypertension. Despite the discontinuation of the medication, she developed acute liver failure and subsequently underwent successful liver transplantation. She survived and had a good clinical outcome.

摘要

我们描述了一名既往无肝脏疾病的女性,她因高血压服用肼苯哒嗪后发生药物性自身免疫性肝炎。尽管停用了该药物,但她仍发展为急性肝衰竭,随后成功接受了肝移植。她存活下来,临床结局良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f39/6855536/1d4e47d2f78e/ac9-6-e00252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f39/6855536/1d4e47d2f78e/ac9-6-e00252-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f39/6855536/1d4e47d2f78e/ac9-6-e00252-g002.jpg

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1
Drug-Induced Autoimmune Hepatitis From Hydralazine Leading to Acute Liver Failure and Liver Transplantation.由肼屈嗪引起的药物性自身免疫性肝炎导致急性肝衰竭及肝移植
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Arch Intern Med. 1979 Jun;139(6):698-9.
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Molecular Idiosyncratic Toxicology of Drugs in the Human Liver Compared with Animals: Basic Considerations.药物在人类肝脏中的分子特异性毒理学与动物比较:基本考虑因素。
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本文引用的文献

1
"Autoimmune(-Like)" Drug and Herb Induced Liver Injury: New Insights into Molecular Pathogenesis."自身免疫(样)"药物和草药诱导的肝损伤:分子发病机制的新见解。
Int J Mol Sci. 2017 Sep 12;18(9):1954. doi: 10.3390/ijms18091954.
2
The use of liver biopsy evaluation in discrimination of idiopathic autoimmune hepatitis versus drug-induced liver injury.肝活检评估在鉴别特发性自身免疫性肝炎与药物性肝损伤中的应用。
Hepatology. 2011 Sep 2;54(3):931-9. doi: 10.1002/hep.24481. Epub 2011 Aug 8.
3
Diagnosis and management of autoimmune hepatitis.自身免疫性肝炎的诊断与管理
Hepatology. 2010 Jun;51(6):2193-213. doi: 10.1002/hep.23584.
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Current concepts of mechanisms in drug-induced hepatotoxicity.药物性肝毒性机制的当前概念。
Curr Med Chem. 2009;16(23):3041-53. doi: 10.2174/092986709788803097.
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Hydralazine-induced cholestatic hepatitis.肼屈嗪诱发的胆汁淤积性肝炎。
Am J Ther. 2009 Jul-Aug;16(4):371-3. doi: 10.1097/MJT.0b013e31817fde85.
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Ann Intern Med. 2002 Dec 17;137(12):947-54. doi: 10.7326/0003-4819-137-12-200212170-00007.
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Epidemiology and individual susceptibility to adverse drug reactions affecting the liver.影响肝脏的药物不良反应的流行病学及个体易感性。
Semin Liver Dis. 2002;22(2):145-55. doi: 10.1055/s-2002-30105.
8
Fulminant hepatic failure caused by ecarazine hydrochloride (a hydralazine derivative).盐酸依卡嗪(一种肼屈嗪衍生物)引起的暴发性肝衰竭。
Hepatology. 1996 Mar;23(3):465-70. doi: 10.1053/jhep.1996.v23.pm0008617425.
9
Hydralazine-induced cholangitis.
Gastroenterology. 1984 Nov;87(5):1185-8.
10
Early indicators of prognosis in fulminant hepatic failure.暴发性肝衰竭预后的早期指标
Gastroenterology. 1989 Aug;97(2):439-45. doi: 10.1016/0016-5085(89)90081-4.