Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity.
作者信息
Gittings Lauren M, Boeynaems Steven, Lightwood Daniel, Clargo Alison, Topia Sarfaraj, Nakayama Lisa, Troakes Claire, Mann David M A, Gitler Aaron D, Lashley Tammaryn, Isaacs Adrian M
机构信息
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, WC1N 3BG, UK.
UK Dementia Research Institute at UCL, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
出版信息
Acta Neuropathol. 2020 Feb;139(2):407-410. doi: 10.1007/s00401-019-02104-x. Epub 2019 Dec 12.
Abstract
摘要
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