Guanghua School of Stomatology, Hospital of Stomatology, and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Stem Cell Rev Rep. 2020 Feb;16(1):41-55. doi: 10.1007/s12015-019-09940-0.
Tooth defect and tooth loss are common clinical diseases in stomatology. Compared with the traditional oral restoration treatment, tooth regeneration has unique advantages and is currently the focus of oral biomedical research. It is known that dozens of cytokines/growth factors and other bioactive factors are expressed in a spatial-temporal pattern during tooth development. On the other hand, the technology for spatial-temporal control of drug release has been intensively studied and well developed recently, making control release of these bioactive factors mimicking spatial-temporal pattern more feasible than ever for the purpose of tooth regeneration. This article reviews the research progress on the tooth development and discusses the future of tooth regeneration in the context of spatial-temporal release of developmental factors.
牙缺损和牙齿缺失是口腔医学中的常见临床疾病。与传统的口腔修复治疗相比，牙齿再生具有独特的优势，目前是口腔生物医学研究的重点。据了解，在牙齿发育过程中，数十种细胞因子/生长因子和其他生物活性因子以时空模式表达。另一方面，药物释放的时空控制技术最近得到了深入研究和充分发展，使得这些生物活性因子的时空模式控制释放比以往任何时候都更可行，从而达到牙齿再生的目的。本文综述了牙齿发育的研究进展，并讨论了在发育因子时空释放的背景下牙齿再生的未来。
