Snetkov Petr, Morozkina Svetlana, Uspenskaya Mayya, Olekhnovich Roman
Institute BioEngineering, ITMO University, Kronverkskiy Prospekt, 49, St. Petersburg 197101, Russia.
Polymers (Basel). 2019 Dec 9;11(12):2036. doi: 10.3390/polym11122036.
Nano- and microfibers based on biopolymers are some of the most attractive issues of biotechnology due to their unique properties and effectiveness. Hyaluronan is well-known as a biodegradable, naturally-occurring polymer, which has great potential for being utilized in a fibrous form. The obtaining of fibers from hyaluronan presents a major challenge because of the hydrophilic character of the polymer and the high viscosity level of its solutions. Electrospinning, as the advanced and effective method of the fiber generation, is difficult. The nano- and microfibers from hyaluronan may be obtained by utilizing special techniques, including binary/ternary solvent systems and several polymers described as modifying (or carrying), such as polyethylene oxide (PEO) and polyvinyl alcohol (PVA). This paper reviews various methods for the synthesis of hyaluronan-based fibers, and also collects brief information on the properties and biological activity of hyaluronan and fibrous materials based on it.
基于生物聚合物的纳米纤维和微纤维因其独特的性能和有效性，成为生物技术中最具吸引力的研究课题之一。透明质酸是一种众所周知的可生物降解的天然聚合物，具有以纤维形式利用的巨大潜力。由于聚合物的亲水性及其溶液的高粘度，从透明质酸中获取纤维是一项重大挑战。静电纺丝作为一种先进且有效的纤维生成方法，在用于从透明质酸制备纤维时存在困难。可以通过利用特殊技术来获得透明质酸纳米纤维和微纤维，这些技术包括二元/三元溶剂体系以及几种被描述为改性（或携带）的聚合物，如聚环氧乙烷（PEO）和聚乙烯醇（PVA）。本文综述了合成基于透明质酸纤维的各种方法，还收集了有关透明质酸及其基纤维材料的性能和生物活性的简要信息。
